1. Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma.
- Author
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Reddemann K, Gola D, Schillert A, Knief J, Kuempers C, Ribbat-Idel J, Ber S, Schemme J, Bernard V, Gebauer N, Feller AC, and Thorns C
- Subjects
- Adult, Aged, Aged, 80 and over, Cell Line, Tumor, Female, Humans, Lymph Nodes pathology, Lymphadenitis pathology, Lymphoma, T-Cell, Peripheral pathology, Male, MicroRNAs genetics, Middle Aged, Gene Expression Regulation, Neoplastic, Lymphadenitis genetics, Lymphoma, T-Cell, Peripheral genetics, MicroRNAs biosynthesis
- Abstract
Background: Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities., Materials and Methods: As a first step towards understanding the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia., Results: We found miR-34a, miR-146a and miR-193b to be up-regulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level., Conclusion: The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Published
- 2015