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The possible use of hydrogen peroxide as an oxidant in the local treatment of the sewage in antibiotic production was investigated. The data on oxidation of SASs and other pollutants in antibiotic production by hydrogen peroxide alone or in the presence of ferrous sulfate as a homogenous catalyst are presented. The influence of the sewage preliminary treatment by hydrogen peroxide on the foaming was studied. It was shown advisable to use the described process for the local treatment as the first stage followed by the sewage electrochemical treatment.

The data on the study of the electrocoagulation treatment of highly concentrated sewage in antibiotic production are presented. Aluminium plates were used as the electrodes. The influence of the anode current density, pH and temperature on the process of the electrocoagulation treatment of the sewage was investigated. The electrocoagulation treatment of the sewage in production of tetracycline, oleandomycin and benzyl-penicillin was shown to be efficient.

The data on the hydrogen peroxide oxidation of surface active substances (SAS) and other pollutants contained in the waste fermentation broth filtrates of antibiotic production are presented. The efficiency of the sewage treatment increased in the presence of FeSO4, a homogeneous catalyst. The influence of the pH value on the efficiency of the treatment was studied with the use of model solutions of the SASs and addition of H2O2. The process of the sewage local treatment with hydrogen peroxide is applicable when the subsequent electrical cleaning is used.

The process of enzymatic hydrolysis of the mycelial waste from the manufacture of tetracycline with using Streptomyces aureofaciens was studied. For the enzymatic hydrolysis, neutral and alkaline proteinases were used. It was shown that alkaline proteinase (protosubtilin G10X) provided the most efficient hydrolysis. Optimal conditions for the hydrolysis were determined: a temperature of 42 degrees C, hydrolysis time of 4 to 6 hours and enzyme concentrations of 1.25 to 2.20 mg/ml at a mycecial waste concentration of 12.5 mg/ml. The time course of changes in amino acid and amine nitrogen levels during enzymatic hydrolysis was investigated. It was demonstrated that the hydrolysis efficiency depended on the mode of enzyme addition. The highest efficiency was observed with fractional feeding of the enzyme.