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Your search keyword '"N. I. Baram"' showing total 1 results
Start Over "N. I. Baram" Journal antibiotiki i khimioterapiia = antibiotics and chemoterapy [sic]
1 results on '"N. I. Baram"'

1. [Pharmacokinetics of the interferon inducer PHL-6 and interferon synthesis in target organs under various methods of drug administration]

Author

F I, Ershov, V I, Sumin, A M, Saĭitkulov, N I, Baram, E B, Tazulakhova, and A I, Ismailov

Subjects
Male, Mice, Viscera, Interferon Inducers, Drug Stability, Mice, Inbred CBA, Administration, Oral, Animals, Brain, Interferons, Organic Chemicals, Injections, Intramuscular
Abstract

The pharmacokinetics of PHL-6 and interferon synthesis dynamic in the target organs (tissues) of mice were studied during its and intraperitoneal administration. In the experimental setting, there was a direct correlation between the interferon production in the murine organs with single PHL-6 and distribution of 14C PHL-6. The highest radioactivity with its oral administration was detected in the liver and intestine. Interferon was actively synthesized in the intestine, liver and serum, showing the levels of 20000, 1024-2048 and 512-1024 IU/ml, respectively. The prolonged action of the drug was in good agreement with the low PHL-6 excretion from the body. It was also shown that almost the whole radiation dose 1 (greater than 98%) was excreted with feces and urine after single and chronic administrations of uniformly labeled PHL-6 which proved important clinical drug use.

Published
1992

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