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Pretreatment of the cultures of human peripheral blood leukocytes and splenocytes with the incubation medium of the mitogen-stimulated human lymphoid cells containing various concentrations of lymphokines (including 10 to 1280 units/ml of immune interferon) resulted in increased (by at least 4 times) production of interferon, induced by staphylococcal enterotoxin A, phytohemagglutinin and mitogen from Phytolacca americana (PWM), as well as in intensification of DNA synthesis in the producing cells. A more pronounced specific binding of the inductor labeled with radioactive iodine to the producing cells was also observed.