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2 results on '"V F, Lopatin"'

1. [Effect of a UHF field on immunogenesis in mice with normal reactivity and with immunodepression induced by rubomycin]

Author

V F, Lopatin, A E, Vatin, and A N, Dedenkov

Subjects
Immunosuppression Therapy, Male, Mice, Time Factors, Radio Waves, Antibody Formation, Daunorubicin, Immunity, Mice, Inbred CBA, Animals, Immunization, Antibody-Producing Cells, Spleen
Abstract

The experiments on male mice of SVA line showed that irradiation in the UHF-field 48 hours after the animal immunization with sheep erythrocytes increased the number of the antibody-producing cells in the spleen at least 3 times. On the background of immunodepression induced by rubomycin the UHF-field increased the primary immune response 2.5 times and the number of cariocytes in the spleen 1.8 times as compared to the control.

Published
1978

2. [Use of carminomycin in combination with UHF hyperthermia in the therapy of sarcoma 180]

Author

V F, Lopatin, A N, Dedenkov, and A E, Vatin

Subjects
Mice, Carubicin, Daunorubicin, Drug Evaluation, Preclinical, Mice, Inbred CBA, Animals, Hyperthermia, Induced, Sarcoma 180, Electromagnetic Phenomena, Neoplasm Transplantation
Abstract

It was found that combined treatment of sarcoma 180 with local U. H. F.-hyperthermia and carminomycin resulted in the tumor growth inhibition by more than 90 per cent, which was much higher than the effect of every agent alone. The thermochemotherapy allowed a decrease in the dose of the antibiotic without decreasing the antitumor effect. The U. H. F.-hyperthermia has an independent tumorolytic effect and promotes selective accumulation of carminomycin by the tumor.

Published
1979

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