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7 results on '"Piccirilli, Alessandra"'

1. Synergistic Activity of Temocillin and Fosfomycin Combination against KPC-Producing Klebsiella pneumoniae Clinical Isolates

Author

Costantino, Venera, primary, Principe, Luigi, additional, Mehat, Jai, additional, Busetti, Marina, additional, Piccirilli, Alessandra, additional, Perilli, Mariagrazia, additional, Luzzati, Roberto, additional, Zerbato, Verena, additional, Meliadò, Antonietta, additional, La Ragione, Roberto, additional, and Di Bella, Stefano, additional

Published
2024
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2. Identification of IncA Plasmid, Harboring blaVIM-1 Gene, in S. enterica Goldcoast ST358 and C. freundii ST62 Isolated in a Hospitalized Patient

Author

Piccirilli, Alessandra, primary, Di Marcantonio, Sascia, additional, Costantino, Venera, additional, Simonetti, Omar, additional, Busetti, Marina, additional, Luzzati, Roberto, additional, Principe, Luigi, additional, Di Domenico, Marco, additional, Rinaldi, Antonio, additional, Cammà, Cesare, additional, and Perilli, Mariagrazia, additional

Published
2023
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5. In Vitro Activity of Sulbactam–Durlobactam against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates: A Multicentre Report from Italy

Author

Segatore, Bernardetta, primary, Piccirilli, Alessandra, additional, Cherubini, Sabrina, additional, Principe, Luigi, additional, Alloggia, Giovanni, additional, Mezzatesta, Maria Lina, additional, Salmeri, Mario, additional, Di Bella, Stefano, additional, Migliavacca, Roberta, additional, Piazza, Aurora, additional, Meroni, Elisa, additional, Fazii, Paolo, additional, Visaggio, Daniela, additional, Visca, Paolo, additional, Cortazzo, Venere, additional, De Angelis, Giulia, additional, Pompilio, Arianna, additional, and Perilli, Mariagrazia, additional

Published
2022
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7. Acinetobacter baumannii Resistance to Sulbactam/Durlobactam: A Systematic Review

Author

Luigi Principe, Stefano Di Bella, Jacopo Conti, Mariagrazia Perilli, Alessandra Piccirilli, Cristina Mussini, Giuliana Decorti, Principe, Luigi, Di Bella, Stefano, Conti, Jacopo, Perilli, Mariagrazia, Piccirilli, Alessandra, Mussini, Cristina, and Decorti, Giuliana

Subjects
Microbiology (medical), Acinetobacter, efficacy, sulbactam/durlobactam, Biochemistry, Microbiology, susceptibility, sulbactam-durlobactam, resistance, Infectious Diseases, resistances, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics
Abstract

Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) have limited therapeutic options. Sulbactam-durlobactam is a combination of two βlactamase inhibitors with activity against CRAB under phase 3 clinical investigation. We performed a systematic review on in vitro studies reporting A. baumannii resistances against sulbactam/durlobactam. We considered “resistant” species to be those with MIC ≥ 8 mg/L. Ten studies were included in the review (9754 tested isolates). Overall, 2.3% of A. baumannii were resistant to sulbactam/durlobactam, and this percentage rose to 3.4% among CRAB subgroups and to 3.7% among colistin-resistant strains. Resistance was 100% among metallo β-lactamase-producing strains. Overall, in 12.5% of cases, sulbactam/durlobactam resistance was associated with the production of NDM-1, in 31.7% of cases with the substitutions in the PBP3 determinants, and in the remaining cases the resistance mechanism was unknown. In conclusion, A. baumannii resistance towards sulbactam/durlobactam is limited, except for MBL-producing strains.

Published
2022

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