1. MICRO-COMPUTED TOMOGRAPHY--CURRENT STATUS AND DEVELOPMENTS.
- Author
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Ritman, Erik L.
- Subjects
- *
TOMOGRAPHY , *X-rays , *BIOPSY , *BIOMEDICAL materials , *ANIMALS , *DRUGS - Abstract
The recent rapid increase in interest in tomographic imaging of small animals and of human (and large animal) organ biopsies is driven largely by drug discovery, cancer detection/monitoring, phenotype identification and/or characterization, and development of disease detection methods and monitoring efficacies of drugs in disease treatment. In biomedical applications, micro-computed tomography (CT) scanners can function as scaled-down (i.e., mini) clinical CT scanners that provide a three-dimensional (3-D) image of most, if not the entire, torso of a mouse at image resolution (50-100 µm) scaled proportional to that of a human CT image. Micro-CT scanners, on the other hand, image specimens the size of intact rodent organs at spatial resolutions from cellular (20 µm) down to subcellular dimensions (e.g., 1 µm) and fill the resolution-hiatus between microscope imaging, which resolves individual cells in thin sections of tissue, and mini-CT imaging of intact volumes. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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