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Portulaca oleracea Linn. has a history of extensive use as a medicinal plant and is a component of the Nigerian ethnomedical pharmacopoeia. Although several studies have been carried out exclusively on the leaves to ascertain the physiological effect, there seems to be dearth of literature on the physiological effect of the stem. This study which was designed to fill this gap investigated the sub-chronic effect of oral administration of chloroform stem extract of P.oleracea (CSEPO) on haematological parameters and plasma activities of some enzymes (Alanine Aminotransferase - ALT, Alkaline Phosphatase - ALP & Aspartate Aminotransferase - AST) and levels of other biochemical parameters such as total protein, albumin, bilirubin, urea and creatinine in male wistar rats. Twenty animals were randomly divided into 4 groups of 5 rats each. Group A(Control) received 0.5 ml of olive oil(vehicle) while Groups B, C & D received 125, 250 & 500 mg/kg body weight of CSEPO respectively for 21 days by oral gavage. At the end, the animals were anaesthetized and blood samples were collected for haematology and plasma biochemical assay. No significant (P > .05) variation occurred in the mean values of ALT, ALP, AST, total protein, albumin, bilirubin, urea, creatinine, Packed Cell Volume (PCV), haemoglobin concentration, RBC, WBC and differential leucocyte counts relative to the control. There was a highly significant (P < .01) increase in the total platelet count only at the dose of 500mg/kg in comparison with control. Oral administration of CSEPO as used in this study had no adverse effect on haematological and biochemical parameters. Secondly, CSEPO may be a useful remedy in thrombocytopenia, due to its potential to increase platelet count. However, further study is recommended in that regards.