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Acute myocardial infraction (AMI) is a leading cause of death in the developed countries. Survival of patients having acute coronary syndrome (ACS) dramatically depends on treatment delay. Hence, a technology that would enable ECG recording immediately after ACS symptom occurrence may significantly decrease AMI mortality. In this study we investigate the signal quality of reconstructed 12-lead ECGs by using 3-lead handheld device with dry electrode in realistic ambulatory conditions. For each subject enrolled in the study an individual transformation matrix was calculated during the calibration procedure, and used for 12-lead reconstruction whenever that subject sends a recording from a handheld device. To evaluate fidelity of 12-lead reconstructions, 3 performance metrics were defined. The results show that the reconstruction error is largest on QRS complex and smallest on ST segment for all 3 metrics. This indicates that the reconstruction of the ST segment, which carries the most important information for ischemia detection, is reconstructed with the highest quality.