1. CYTOGENOTOXICITY OF AQUEOUS EXTRACTS OF LEAVES AND SEEDS OF GEGEMU (DATURA STRAMONIUM) ON ALLIUM CEPA.
- Author
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ASHIRU, Olayinka Murtala, SIFAU, Mutiu Oyekunle, and OLUWATONILOBA, Onikoyi
- Subjects
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DATURA stramonium , *ONIONS , *SEEDS , *CHROMOSOME abnormalities , *EXTRACTS , *ALLIUM - Abstract
Cytogenotoxicity effects of aqueous extract of Datura stramonium leaves and seeds were investigated on root cells of Allium cepa by employing Allium cepa assay. A. cepa roots were treated with the aqueous extracts of both the leaves and seeds at five different concentrations (12.5, 25, 50, 75, and 100 p.p.m) each for 72h. Exposure of aqueous extracts of both the leaves and seeds increased mitotic index, and total chromosomal aberrations by the Allium test. While chromosome laggards, stickiness, disturbed anaphase--telophase and anaphase bridges were observed in anaphase--telophase cells, c-metaphase and binuclear cells were observed in other cells. These results indicate that aqueous extracts of both the leaves and seeds exhibits genotoxic activity in A. cepa root meristematic cells. [ABSTRACT FROM AUTHOR]
- Published
- 2020