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The nasal carriage rate of Staphylococcus aureus among maternal-infant pairs was 18% compared with 39% among hospital staff in Ile-Ife, Nigeria during a 12-week survey. Of the newborns, 46% tested positive compared with 26% of their mothers. The S. aureus phage types recovered were predominantly of the group III type (38%); however, 28% of the strains isolated were non-typable. All the S. aureus strains were resistant to penicillin, 84% to tetracycline, and 35 and 24% were resistant to streptomycin and chloramphenicol, respectively. Altogether 19% of the strains tested were resistant to methicillin.

A total of 247 bacterial isolates were obtained from diarrhoeal patients aged 0-60 months in an oral rehydration therapy clinic in Ibadan and tested for sensitivity to 11 antibiotics using the disc diffusion method. Fifty isolates obtained from apparently healthy age-matched controls were similarly tested. The results show that 6(2.4%) of the isolates obtained from the diarrhoeal children were resistant to all the 11 antibiotics used in the test and that most of the others were resistant to several antibiotics. Similarly, a very considerable percentage of isolates obtained from children in the control group were found to be resistant to several antibiotics. It is therefore apparent that there is a high incidence of multiply-antibiotic-resistant isolates within the sample environment.

Children under 2 years of age are most susceptible to acute respiratory infections caused by Bordetella pertussis, Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis. We analysed milk samples and sera from mother-infant pairs for specific antibodies that may enhance protection against the bacterial pathogens. The results show that the breast-milk samples contained significant titres of specific IgG and IgA antibodies to the four organisms, although the mean IgG antibody levels were higher in maternal sera than in breast-milk. On the other hand, the mean IgA antibody levels to the four organisms were higher in breast-milk than in both maternal and infant sera. IgM antibodies to these organisms were relatively low or absent in many milk and serum samples. Nevertheless, the significant concentrations of specific IgG and IgA antibodies in milk samples may indicate a protective role for breast-milk against the four infections in early childhood.