1. Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
- Author
-
Crowson, Cynthia S, Rollefstad, Silvia, Ikdahl, Eirik, Kitas, George D, van Riel, Piet LCM, Gabriel, Sherine E, Matteson, Eric L, Kvien, Tore K, Douglas, Karen, Sandoo, Aamer, Arts, Elke, Wållberg-Jonsson, Solveig, Innala, Lena, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol, Ramos, Virginia Pascual, Yáñez, Irazú Contreras, Sfikakis, Petros P, Zampeli, Evangelia, Gonzalez-Gay, Miguel A, Corrales, Alfonso, Laar, Mart van de, Vonkeman, Harald E, Meek, Inger, and Semb, Anne Grete
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Cardiovascular ,Aging ,Prevention ,Rheumatoid Arthritis ,Clinical Research ,Heart Disease ,Arthritis ,Autoimmune Disease ,2.4 Surveillance and distribution ,2.3 Psychological ,social and economic factors ,Aetiology ,Inflammatory and immune system ,Good Health and Well Being ,Adult ,Aged ,Arthritis ,Rheumatoid ,Cardiovascular Diseases ,Cholesterol ,Cohort Studies ,Female ,Follow-Up Studies ,Humans ,Hypertension ,Incidence ,Male ,Middle Aged ,Risk Factors ,Severity of Illness Index ,Sex Factors ,Smoking ,A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis ,Cardiovascular disease ,population attributable risk ,rheumatoid arthritis ,risk factor ,Public Health and Health Services ,Arthritis & Rheumatology ,Clinical sciences - Abstract
ObjectivesPatients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA.MethodsIn 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions.Results5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p
- Published
- 2018