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Background Ultrasound (US) is playing an increasingly important role in the early evaluation of psoriatic arthritis (PsA) being capable of detecting inflammatory changes at the enthesis, synovium and extra capsular tissues. Peri-articular radiographic erosions in PsA and rheumatoid arthritis are associated with a worse outcome. Further, US is shown to be a more sensitive imaging technique than conventional radiography (CR) to identify erosions in early RA. By contrast, there is a paucity of data in the literature on the prevalence of erosions and/or the capability of US to detect erosions in early PsA. Objectives To assess the prevalence of erosions in early PsA using CR and high resolution US. Methods We studied 860 joints of 43 patients (Table 1) with early PsA, all fulfilling CASPAR criteria from the Leeds Spondyloarthropathy Register for Research and Observation study (SpARRO) which is a prospective longitudinal observational cohort of patients with early spondyloarthritis. Radiographic and sonographic erosions of the wrists, MCPs (2, 3), PIPs (2, 3), and MTPs (1–5) bilaterally were independently evaluated. We looked at the frequency of erosions using both imaging methodologies. CR and US scoring systems used for defining erosions were the van der Heijde version of the Sharp and OMERACT respectively. Results Erosions were identified in a total of 8 patients, all negative for RF and CCP antibodies; 40% (3/8) of whom were ex-smokers. Four patients had six erosions at MTP4, MTP5, and PIP3 by CR whilst six patients had six erosions on US. The exact agreement between the 2 methods was 99%. Agreement on absence of erosions in both CR and US was 99% while agreement on their presence was 17%. The proportions of joints where the CR and US disagreed in either direction (US>XR, US Conclusions In keeping with the emerging data in PsA, these results show a low frequency of erosions at clinical presentation on CR. Unlike studies in early RA, in this preliminary study of early PsA the burden of erosive disease detected using US was not measurably different. References Weiner, S M,Jurenz, S,Uhl, M,Lange-Nolde, A,Warnatz, K,Peter, H H,Walker, U A.Ultrasonography in the assessment of peripheral joint involvement in psoriatic arthritis: a comparison with radiography, MRI and scintigraphy. Clinical rheumatology, vol. 27, no. 8, p. 983–989, 0770–3198 (August 2008) Acknowledgement Dr Richard Fawcett who works as a radiology fellow at Chapel Allerton Hospital Disclosure of Interest None declared

Background Up to 20% of inflammatory bowel diseases (IBD) cases may have an associated form of Spondyloarthropathy (SpA). Axial disease in SpA may vary from sporadic back pain to advanced spinal fusion, undistinguishable from Ankylosing Spondylitis (AS). Magnetic resonance imaging (MRI) is well established in the assessment of spinal disease in SpA, but axial MRI data in IBD are still sparse. In AS and axial Psoriatic Arthritis (PsA), it has previously been shown that the extent and severity of inflammatory changes of bone marrow oedema (BMO) on MRI is related to HLA-B27. Objectives The aims of this study were to describe the prevalence and extent of BMO lesions and their relationship with HLA-B27 status in IBD-related SpA with axial symptoms. Methods Consecutive MRI scans [thoracic spine (TS), lumbar spine (LS) and sacroiliac joints (SIJs)], from patients attending the Leeds Combined Rheumatology and Gastroenterology service between 2005–2015, were assessed retrospectively. Scans had been performed as part of clinical assessment for inflammatory back pain. All subjects had histological diagnosis of IBD and fulfilled ASAS classification criteria for SpA, HLA-B27 status and demographics were also collected. MRI scans were scored by consensus by two expert readers, blinded to the clinical characteristics of the patients. We used the semiquantitative (0–3) Leeds MRI Scoring System for BMO lesions representative of inflammation in the spine and SIJs, whereby a lesion graded as moderate (grade 2) is considered clinically significant. Concordant data from the two readers were used to report on definite lesions. Results MRI scans from 43 patients were available for analysis; mean age 43.4 yrs (SD 13.2, range 18.1–80.9), 25 were females (58.1%). Mean age at SpA diagnosis was 37.1 yrs (SD 11.9, range 17.1–63). HLA-B27 was positive in 15 subjects (34.9%) and was associated with younger age at SpA diagnosis (p=0.015). The median MRI score and number of BMO lesions were 2 (IQR 0–7 and 0–5, respectively), 13 patients (30.2%) scored zero, 14 subjects (32.6%) showed at least 1 clinically relevant lesion (grade ≥2). Gender, current age or age at MRI scan were not associated with HLA-B27. MRI total (whole axial skeleton) and partial (TS, LS and SIJs single analysis) score, number of BMO lesions and severe lesions (total axial skeleton and TS-LS-SIJs single analysis) were not different according to HLA B27 status. Conclusions Although the majority of IBD-related SpA do not carry HLA B27, diagnosis at a younger age was related to HLA-B27 status. Axial BMO lesions in IBD disease showed the whole spectrum of changes noted in AS. Unlike AS and axial PsA, no association was found between the extent and severity of MRI-determined axial disease and HLA-B27. Disclosure of Interest None declared