1. Clinical symptoms and associated vascular imaging findings in Takayasu's arteritis compared to giant cell arteritis
- Author
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Despina Michailidou, Joel S. Rosenblum, Casey A. Rimland, Jamie Marko, Peter C. Grayson, and Mark A. Ahlman
- Subjects
Adult ,Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Immunology ,Takayasu's arteritis ,Giant Cell Arteritis ,Carotidynia ,General Biochemistry, Genetics and Molecular Biology ,Magnetic resonance angiography ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Rheumatology ,Fluorodeoxyglucose F18 ,Occlusion ,medicine ,Immunology and Allergy ,Humans ,Aged ,030203 arthritis & rheumatology ,Neck Pain ,medicine.diagnostic_test ,business.industry ,Headache ,Intermittent Claudication ,Middle Aged ,medicine.disease ,Takayasu Arteritis ,Stenosis ,Giant cell arteritis ,Carotid Arteries ,Positron-Emission Tomography ,Female ,Radiology ,Radiopharmaceuticals ,Symptom Assessment ,business ,Vasculitis ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
ObjectiveTo compare the presence of head, neck and upper extremity symptoms in patients with Takayasu’s (TAK) and giant cell arteritis (GCA) and their association with vascular inflammation assessed by18F-fluorodeoxyglucose positron emission tomography (FDG-PET) or arterial damage assessed by magnetic resonance angiography (MRA).MethodsPatients with TAK and GCA underwent clinical and imaging assessments within 24 hours, blinded to each other. Vascular inflammation was defined as arterial FDG-PET uptake greater than liver by visual assessment. Arterial damage was defined as stenosis, occlusion, or aneurysm by MRA. Clinically reported symptoms were compared with corresponding imaging findings using generalised mixed model regression. Cranial symptoms were studied in association with burden of arterial disease in the neck using ordinal regression.ResultsParticipants with TAK (n=56) and GCA (n=54) contributed data from 270 visits. Carotidynia was reported only in patients with TAK (21%) and was associated with vascular inflammation (pConclusionThe distribution of symptoms and association with imaging abnormalities differs in patients with TAK and GCA. These findings may help clinicians predict associated FDG-PET and MRA findings based on a specific clinical symptom.Clinical trial registration numberNCT02257866.
- Published
- 2019