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Start Over Author "Warnick JE" Journal annals of the new york academy of sciences
3 results on '"Warnick JE"'

1. Trophic functions of the neuron. 3. Mechanisms of neurotrophic interactions. The effects of vinblastine and colchicine on neural regulation of muscle.

Author

Albuquerque EX, Warnick JE, Sansone FM, and Onur R

Subjects
Acetylcholine pharmacology, Action Potentials drug effects, Adenosine Triphosphatases metabolism, Animals, Caffeine pharmacology, Cell Membrane metabolism, Cycloheximide pharmacology, Electrophysiology, Iontophoresis, Membrane Potentials drug effects, Microtubules metabolism, Muscle Contraction, Nerve Degeneration, Neuromuscular Junction drug effects, Rats, Sarcoplasmic Reticulum metabolism, Tetrodotoxin pharmacology, Time Factors, Colchicine pharmacology, Muscles innervation, Peripheral Nerves drug effects, Vinblastine pharmacology
Published
1974
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2. Junctional and extrajunctional aspects of inherited muscular dystrophy in chickens: development and pharmacology.

Author

Warnick JE, Lebeda FJ, and Albuquerque EX

Subjects
Acetylcholine pharmacology, Action Potentials, Animals, Chickens, Membrane Potentials, Motor Endplate drug effects, Motor Endplate physiopathology, Muscle Denervation, Muscles drug effects, Muscles physiopathology, Neurotransmitter Agents metabolism, Penicillamine pharmacology, Posture, Species Specificity, Muscular Dystrophy, Animal physiopathology, Neuromuscular Junction physiopathology
Published
1979
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3. Recent advances in the molecular mechanisms of human and animal models of myasthenia gravis.

Author

Albuquerque EX, Warnick JE, Mayer RF, Eldefrawi AT, and Eldefrawi ME

Subjects
Acetylcholine pharmacology, Action Potentials, Animals, Cholinesterase Inhibitors pharmacology, Humans, Intercostal Muscles metabolism, Intercostal Muscles physiopathology, Ion Channels metabolism, Membrane Potentials drug effects, Motor Endplate physiopathology, Myasthenia Gravis drug therapy, Myasthenia Gravis physiopathology, Rabbits, Myasthenia Gravis metabolism, Receptors, Cholinergic analysis
Abstract

The receptor-channel molecule is a dynamic system which exists in multiple conformations and that is the way we should think of it when we study antibody interaction with the molecule. The results presented here suggest that some antibodies may affect receptor function by occupying sites other than the receptor site. Some of these sites may by exposed only in certain conformations, and occupation of some site by antibodies may effect conformational changes. These small but perhaps important differences in cholinergic channel properties of the myasthenic muscle from the normal one are revealed by studying the effect of myasthenic sera on drug interactions with the channel sites. The sera of myasthenics are able to react with certain channel conformations and are able to affect the interaction of channel antagonists such as H12HTX and QNB. The sera appear to act preferentially with the open conformation of the channel. As a consequence of such an effect, important conformational changes of the channel may fail to occur upon activation.

Published
1981
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