1. Chemokines as novel therapeutic targets for inflammatory bowel disease
- Author
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Miyuki Nishimura, Tetsu Kawano, Kenzo Muramoto, Yoshikazu Kuboi, and Toshio Imai
- Subjects
Receptors, CCR6 ,Chemokine ,Inflammation ,Disease ,Inflammatory bowel disease ,Models, Biological ,General Biochemistry, Genetics and Molecular Biology ,Chemokine receptor ,Receptors, CCR ,History and Philosophy of Science ,medicine ,Humans ,Receptor ,Crohn's disease ,Chemokine CCL20 ,biology ,business.industry ,Chemokine CX3CL1 ,General Neuroscience ,medicine.disease ,Inflammatory Bowel Diseases ,Ulcerative colitis ,digestive system diseases ,Chemokines, CC ,Immunology ,biology.protein ,medicine.symptom ,business ,Signal Transduction - Abstract
The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self-destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration into the intestine is fundamental event in disease development and progression where the chemokines and their receptors are orchestrating the tissue-specific and the cell type-selective trafficking of leukocytes. In this review, we will discuss the homeostatic and inflammatory roles of the chemokines and their receptors with their potentials and promise as molecular targets for therapeutic interventions in human IBD, focusing on the recently identified role of the CX3CL1-CX3CR1 axis, as well as the CCL20-CCR6, CCL25-CCR9, and CXCL10-CXCR3 pathways.
- Published
- 2009