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Start Over Author "Leonard SW" Journal annals of the new york academy of sciences
2 results on '"Leonard SW"'

1. Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations.

Author

Lim Y, Schock BC, Gohil K, Leonard SW, Packer L, Cross CE, and Traber MG

Subjects
Animals, Carrier Proteins physiology, Mice, Mice, Knockout, alpha-Tocopherol administration & dosage, Carrier Proteins genetics, Diet, Vitamin E administration & dosage, alpha-Tocopherol analysis
Published
2004
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2. Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.

Author

Leonard SW, Bruno RS, Ramakrishnan R, Bray T, and Traber MG

Subjects
Adolescent, Adult, Chromans urine, Female, Humans, Male, alpha-Tocopherol administration & dosage, alpha-Tocopherol blood, alpha-Tocopherol pharmacokinetics, Chromans blood, Deuterium, Nutritional Requirements, Smoking adverse effects, Vitamin E administration & dosage
Abstract

Cigarette smoking (CS) is a well-described oxidant burden in humans. We hypothesized that CS would accelerate alpha-tocopherol (alpha-T) utilization leaving less for metabolite (CEHC) production. After labeled alpha-T consumption (75 mg each of d(3)-RRR-alpha-TAc and d(6)-all-rac-alpha-TAc) by smokers and nonsmokers (n = 10/group), CS increased alpha-T disappearance and decreased plasma and urinary CEHCs. Plasma d(3)/d(6)-alpha-T ratios were approximately 1.4 during supplementation and approximately 2 from days 5 to 17. d(3)/d(6)-alpha-CEHC ratios were on average 0.29 +/- 0.05, confirming that all-rac-alpha-tocopherol is metabolized more efficiently. CEHC may be a good marker of vitamin E status, and smokers may have an increased vitamin E requirement.

Published
2004
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