Search

Your search keyword '"Grünebach F"' showing total 2 results
Start Over Author "Grünebach F" Journal annals of the new york academy of sciences
2 results on '"Grünebach F"'

2. Dendritic cell-based vaccines in patients with hematological malignancies.

Author

Brugger W, Schneider A, Schammann T, Dill P, Grünebach F, Bühring HJ, Kanz L, and Brossart P

Subjects
Acute Disease, Antigen Presentation, Antigens, Neoplasm biosynthesis, Antigens, Neoplasm chemistry, Breast Neoplasms immunology, Breast Neoplasms therapy, Carcinoma immunology, Carcinoma therapy, Cytotoxicity, Immunologic, Epitopes immunology, Female, HLA-A2 Antigen biosynthesis, Hematologic Neoplasms immunology, Humans, Immunization, Leukemia, Myeloid pathology, Male, Minisatellite Repeats, Mucin-1 biosynthesis, Mucin-1 chemistry, Neoplasm Proteins biosynthesis, Neoplasm Proteins chemistry, Neoplasm, Residual therapy, Neoplastic Stem Cells metabolism, Ovarian Neoplasms immunology, Ovarian Neoplasms therapy, Protein Sorting Signals, Vaccination, Antigens, Neoplasm immunology, Cancer Vaccines immunology, Dendritic Cells immunology, HLA-A2 Antigen immunology, Hematologic Neoplasms therapy, Immunotherapy, Active, Leukemia, Myeloid immunology, Mucin-1 immunology, Neoplasm Proteins immunology, Peptide Fragments immunology, T-Lymphocytes, Cytotoxic immunology
Abstract

The epithelial mucin MUC1 is overexpressed on many epithelial malignancies as well as on some B-cell lymphomas and multiple myelomas. In the present study, we described MUC1 expression also on primary AML blasts. To analyze the presentation of MUC1-derived HLA-A2 restricted peptides by primary AML blasts, we induced MUC1-specific cytotoxic T-lymphocytes (CTLs) in vitro using peptide pulsed dendritic cells from HLA-A2+ healthy donors as antigen-presenting cells. These CTLs efficiently lysed primary AML blasts that constitutively expressed both MUC1 and HLA-A2. The specificity of the CTLs was confirmed in a cold target inhibition assay. Our data demonstrate that MUC1-derived peptides are tumor antigens in AML which could potentially be used for immunotherapeutic approaches.

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results