1. Endotherapy for and tailored approaches to treating GERD, and refractory GERD.
- Author
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Locke, G. Richard, Horwhat, John, Mashimo, Hiroshi, Savarino, Edoardo, Zentilin, Patrizia, Savarino, Vincenzo, Zerbib, Frank, Armbruster, Steven P., Wong, Roy K., and Moawad, Fouad
- Subjects
GASTROESOPHAGEAL reflux treatment ,INFLAMMATORY bowel diseases ,FUNDOPLICATION ,SYMPTOMS ,COMPARATIVE studies ,SENSORY receptors - Abstract
This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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