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The aim of the present systematic review is to critically appraise the current evidence from published medical trials on the role of programmed second endoscopy with appropriate therapy on peptic ulcer re-bleeding. A systematic review of five prospective randomized controlled trials comparing the effect of programmed second endoscopy against conservative management on peptic ulcer re-bleeding was carried out. From the meta-analysis of the combined results from the five trials on the effect of programmed second endoscopy in ulcer bleeding, we found that a programmed second endoscopy with appropriate therapy reduced the number of recurrent bleeding significantly (Peto odds ratio = 1.97, Mantel Haenszel-Peto P < 0.01). The number of patients needed for treatment with a programmed second endoscopy in order to prevent one recurrent bleeding ranged from four to 11. Programmed second endoscopy with appropriate therapy reduced the number of recurrent bleeding significantly in patients with bleeding peptic ulcers. Individual trials also showed a possible benefit in reduction of the number of surgical interventions. [ABSTRACT FROM AUTHOR]

To discuss the relationship between CO[SUB2] pneumoperitoneum and haemorrheology and the possibility of thrombosis caused by CO[SUB2]. Material and Methods: We compared indices of haemorrheology just prior to operation, 5 min after anaesthesia and 30 min after inflation or operation, and 24h after operation. The indices included low-shear and high-shear whole-blood relative viscosity; plasma relative viscosity; red cell aggregation index; red cell filtration index; haematocrit; and blood gas analysis. We analysed the relationship between a variation in haemorrheology and CO[SUB2] pneumoperitoneum. Results: After pneumoperitoneum, blood viscosity and red cell aggregation index rises markedly and red cell deformity weakens markedly. Conclusion: Carbon dioxide pneumoperitoneum can cause an increase in blood viscosity, red cell aggregation and a weakening of red cell deformity, and may lead to thrombosis after laparoscopic surgery. [ABSTRACT FROM AUTHOR]