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Start Over Author "Olthof, Pim" Journal annals of surgical oncology
19 results on '"Olthof, Pim"'

1. Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort

Author

Olthof, Pim B., Bouwense, Stefan A. W., Bednarsch, Jan, Dewulf, Maxime, Kazemier, Geert, Maithel, Shishir, Jarnagin, William R., Aldrighetti, Luca, Roberts, Keith J., Troisi, Roberto I., Malago, Massimo M., Lang, Hauke, Alikhanov, Ruslan, Ruzzenente, Andrea, Malik, Hassan, Charco, Ramón, Sparrelid, Ernesto, Pratschke, Johann, Cescon, Matteo, Nadalin, Silvio, Hagendoorn, Jeroen, Schadde, Erik, Hoogwater, Frederik J. H., Schnitzbauer, Andreas A., Topal, Baki, Lodge, Peter, Olde Damink, Steven W. M., Neumann, Ulf P., and Groot Koerkamp, Bas

Published
2024
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2. Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease

Author

van Keulen, Anne-Marleen, Buettner, Stefan, Olthof, Pim B., Klümpen, Heinz-Josef, Erdmann, Joris I., Izquierdo-Sanchez, Laura, Banales, Jesus M., Goeppert, Benjamin, Roessler, Stephanie, Zieniewicz, Krzysztof, Lamarca, Angela, Valle, Juan W., La Casta, Adelaida, Hoogwater, Frederik J. H., Donadon, Matteo, Scheiter, Alexander, Marzioni, Marco, Adeva, Jorge, Kiudeliene, Edita, Fernández, Jesús María Urman, Vidili, Gianpaolo, Mocan, Tudor, Fabris, Luca, Krawczyk, Marcin, Folseraas, Trine, Dopazo, Cristina, Detry, Olivier, Voiosu, Theodor, Scripcariu, Viorel, Biancaniello, Francesca, Braconi, Chiara, Macias, Rocio I. R., and Groot Koerkamp, Bas

Published
2024
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4. Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible

Author

Olthof, Pim B., Erdmann, Joris I., Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik J. H., Jarnagin, William R., Kazemier, Geert, Lang, Hauke, Maithel, Shishir K., Malago, Massimo, Malik, Hassan Z., Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W. M., Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J., Schadde, Erik, Schnitzbauer, Andreas A., Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I., and Groot Koerkamp, Bas

Published
2024
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6. ASO Visual Abstract: Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease

Author

van Keulen, Anne-Marleen, Buettner, Stefan, Olthof, Pim B., Klümpen, Heinz-Josef, Erdmann, Joris I., Izquierdo-Sanchez, Laura, Banales, Jesus M., Goeppert, Benjamin, Roessler, Stephanie, Zieniewicz, Krzysztof, Lamarca, Angela, Valle, Juan W., La Casta, Adelaida, Hoogwater, Frederik J. H., Donadon, Matteo, Scheiter, Alexander, Marzioni, Marco, Adeva, Jorge, Kiudeliene, Edita, Fernández, Jesús María Urman, Vidili, Gianpaolo, Mocan, Tudor, Fabris, Luca, Krawczyk, Marcin, Folseraas, Trine, Dopazo, Cristina, Detry, Olivier, Voiosu, Theodor, Scripcariu, Viorel, Biancaniello, Francesca, Braconi, Chiara, Macias, Rocio I. R., and Groot Koerkamp, Bas

Published
2024
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10. Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma

Author

Vugts, Jaynee J. A., Gaspersz, Marcia P., Roos, Eva, Franken, Lotte C., Olthof, Pim B., Coelen, Robert J. S., van Vugt, Jeroen L. A., Labeur, Tim A., Brouwer, Lieke, Besselink, Marc G. H., IJzermans, Jan N. M., Darwish Murad, Sarwa, van Gulik, Thomas M., de Jonge, Jeroen, Polak, Wojciech G., Busch, Olivier R. C., Erdmann, Joris L., Groot Koerkamp, Bas, and Buettner, Stefan

Published
2021
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11. ASO Visual Abstract: The Influence of Hepatic Steatosis and Fibrosis on Postoperative Outcomes After Major Liver Resection of Perihilar Cholangiocarcinoma

Author

van Keulen, Anne-Marleen, primary, Olthof, Pim B., additional, Buettner, Stefan, additional, Bednarsch, Jan, additional, Verheij, Joanne, additional, Erdmann, Joris I., additional, Nooijen, Lynn E., additional, Porte, Robert J., additional, Minnee, Robert C., additional, Darwish Murad, Sarwa, additional, Neumann, Ulf P., additional, Heij, Lara, additional, Groot Koerkamp, Bas, additional, and Doukas, Michail, additional

Published
2023
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13. Correction to: Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma

Author

Vugts, Jaynee J. A., Gaspersz, Marcia P., Roos, Eva, Franken, Lotte C., Olthof, Pim B., Coelen, Robert J. S., van Vugt, Jeroen L. A., Labeur, Tim A., Brouwer, Lieke, Besselink, Marc G. H., IJzermans, Jan N. M., Murad, Sarwa Darwish, van Gulik, Thomas M., de Jonge, Jeroen, Polak, Wojciech G., Busch, Olivier R. C., Erdmann, Joris L., Koerkamp, Bas Groot, and Buettner, Stefan

Published
2021
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15. Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative Group

Author

Ruzzenente, Andrea, Bagante, Fabio, Olthof, Pim B, Aldrighetti, Luca, Alikhanov, Ruslan, Cescon, Matteo, Koerkamp, Bas Groot, Jarnagin, William R, Nadalin, Silvio, Pratschke, Johann, Schmelzle, Moritz, Sparrelid, Ernesto, Lang, Hauke, Iacono, Calogero, van Gulik, Thomas M, Guglielmi, Alfredo, Andreou A, Bartsch F, Benzing C, Buettner S, Campagnaro T, Capobianco I, Charco R, de Reuver P, de Savornin, Lohman E, Nijmegen, Dejong CHC, Efanov M, Erdmann JI, Franken LC, Giovinazzo G, Giglio MC, Gomez-Gavara C, Heid F, IJzermans JNM, Isaac J, Jansson H, Ligthart MAP, Maithel SK, Malago` M. Malik HZ, Muiesan P, Olde Damink SWM, Quinn LM, Ratti F, Ravaioli M, Rolinger J, Schadde E, Serenari M, Troisi R, van Laarhoven S, van Vugt JLA, Faculteit Medische Wetenschappen/UMCG, Surgery, Ruzzenente, Andrea, Bagante, Fabio, Olthof, Pim B, Aldrighetti, Luca, Alikhanov, Ruslan, Cescon, Matteo, Koerkamp, Bas Groot, Jarnagin, William R, Nadalin, Silvio, Pratschke, Johann, Schmelzle, Moritz, Sparrelid, Ernesto, Lang, Hauke, Iacono, Calogero, van Gulik, Thomas M, Guglielmi, Alfredo, Andreou, A, Bartsch, F, Benzing, C, Buettner, S, Campagnaro, T, Capobianco, I, Charco, R, de Reuver, P, De, Savornin, Lohman, E, Nijmegen, Dejong, Chc, Efanov, M, Erdmann, Ji, Franken, Lc, Giovinazzo, G, Giglio, Mc, Gomez-Gavara, C, Heid, F, Ijzermans, Jnm, Isaac, J, Jansson, H, Ligthart, Map, Maithel, Sk, Malago` M., Malik HZ, Muiesan, P, Olde Damink, Swm, Quinn, Lm, Ratti, F, Ravaioli, M, Rolinger, J, Schadde, E, Serenari, M, Troisi, R, van Laarhoven, S, van Vugt, Jla, Ruzzenente, A., Bagante, F., Olthof, P. B., Aldrighetti, L., Alikhanov, R., Cescon, M., Koerkamp, B. G., Jarnagin, W. R., Nadalin, S., Pratschke, J., Schmelzle, M., Sparrelid, E., Lang, H., Iacono, C., van Gulik, T. M., Guglielmi, A., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Campagnaro, T., Capobianco, I., Charco, R., de Reuver, P., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Giovinazzo, G., Giglio, M. C., Gomez-Gavara, C., Heid, F., Ijzermans, J. N. M., Isaac, J., Jansson, H., Ligthart, M. A. P., Maithel, S. K., Malago, M., Malik, H. Z., Muiesan, P., Damink, S. W. M. O., Quinn, L. M., Ratti, F., Ravaioli, M., Rolinger, J., Schadde, E., Serenari, M., Troisi, R., van Laarhoven, S., van Vugt, J. L. A., CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
medicine.medical_specialty, medicine.medical_treatment, Perineural invasion, Metastasis, Cholangiocarcinoma, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Surgical oncology, Medicine, Hepatectomy, Humans, Perihilar Cholangiocarcinoma, Contraindication, Retrospective Studies, business.industry, Incidence (epidemiology), medicine.disease, Surgery, Oncology, Bile Duct Neoplasms, Cohort, business, Bismuth, Klatskin Tumor
Abstract

Background Although Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) is no longer considered a contraindication for curative surgery, few data are available from Western series to indicate the outcomes for these patients. This study aimed to compare the short- and long-term outcomes for patients with BC type 4 versus BC types 2 and 3 pCCA undergoing surgical resection using a multi-institutional international database. Methods Uni- and multivariable analyses of patients undergoing surgery at 20 Western centers for BC types 2 and 3 pCCA and BC type 4 pCCA. Results Among 1138 pCCA patients included in the study, 826 (73%) had BC type 2 or 3 disease and 312 (27%) had type 4 disease. The two groups demonstrated significant differences in terms of clinicopathologic characteristics (i.e., portal vein embolization, extended hepatectomy, and positive margin). The incidence of severe complications was 46% for the BC types 2 and 3 patients and 51% for the BC type 4 patients (p = 0.1). Moreover, the 90-day mortality was 13% for the BC types 2 and 3 patients and 12% for the BC type 4 patients (p = 0.57). Lymph-node metastasis (N1; hazard-ratio [HR], 1.62), positive margins (R1; HR, 1.36), perineural invasion (HR, 1.53), and poor grade of differentiation (HR, 1.25) were predictors of survival (all p ≤0.004), but BC type was not associated with prognosis. Among the N0 and R0 patients, the 5-year overall survival was 43% for the patients with BC types 2 and 3 pCCA and 41% for those with BC type 4 pCCA (p = 0.60). Conclusions In this analysis of a large Western multi-institutional cohort, resection was shown to be an acceptable curative treatment option for selected patients with BC type 4 pCCA although a more technically challenging surgical approach was required.

Published
2020

16. Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma

Author

Vugts, Jaynee J. A., primary, Gaspersz, Marcia P., additional, Roos, Eva, additional, Franken, Lotte C., additional, Olthof, Pim B., additional, Coelen, Robert J. S., additional, van Vugt, Jeroen L. A., additional, Labeur, Tim A., additional, Brouwer, Lieke, additional, Besselink, Marc G. H., additional, IJzermans, Jan N. M., additional, Darwish Murad, Sarwa, additional, van Gulik, Thomas M., additional, de Jonge, Jeroen, additional, Polak, Wojciech G., additional, Busch, Olivier R. C., additional, Erdmann, Joris L., additional, Groot Koerkamp, Bas, additional, and Buettner, Stefan, additional

Published
2020
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17. Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative Group.

Author

Ruzzenente A, Bagante F, Olthof PB, Aldrighetti L, Alikhanov R, Cescon M, Koerkamp BG, Jarnagin WR, Nadalin S, Pratschke J, Schmelzle M, Sparrelid E, Lang H, Iacono C, van Gulik TM, and Guglielmi A

Subjects
Bismuth, Hepatectomy, Humans, Retrospective Studies, Bile Duct Neoplasms surgery, Cholangiocarcinoma surgery, Klatskin Tumor surgery
Abstract

Background: Although Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) is no longer considered a contraindication for curative surgery, few data are available from Western series to indicate the outcomes for these patients. This study aimed to compare the short- and long-term outcomes for patients with BC type 4 versus BC types 2 and 3 pCCA undergoing surgical resection using a multi-institutional international database., Methods: Uni- and multivariable analyses of patients undergoing surgery at 20 Western centers for BC types 2 and 3 pCCA and BC type 4 pCCA., Results: Among 1138 pCCA patients included in the study, 826 (73%) had BC type 2 or 3 disease and 312 (27%) had type 4 disease. The two groups demonstrated significant differences in terms of clinicopathologic characteristics (i.e., portal vein embolization, extended hepatectomy, and positive margin). The incidence of severe complications was 46% for the BC types 2 and 3 patients and 51% for the BC type 4 patients (p = 0.1). Moreover, the 90-day mortality was 13% for the BC types 2 and 3 patients and 12% for the BC type 4 patients (p = 0.57). Lymph-node metastasis (N1; hazard-ratio [HR], 1.62), positive margins (R1; HR, 1.36), perineural invasion (HR, 1.53), and poor grade of differentiation (HR, 1.25) were predictors of survival (all p ≤0.004), but BC type was not associated with prognosis. Among the N0 and R0 patients, the 5-year overall survival was 43% for the patients with BC types 2 and 3 pCCA and 41% for those with BC type 4 pCCA (p = 0.60)., Conclusions: In this analysis of a large Western multi-institutional cohort, resection was shown to be an acceptable curative treatment option for selected patients with BC type 4 pCCA although a more technically challenging surgical approach was required., (© 2021. The Author(s).)

Published
2021
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19. Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma.

Author

Olthof PB, Aldrighetti L, Alikhanov R, Cescon M, Groot Koerkamp B, Jarnagin WR, Nadalin S, Pratschke J, Schmelze M, Sparrelid E, Lang H, Guglielmi A, and van Gulik TM

Subjects
Aged, Hepatectomy adverse effects, Humans, Male, Middle Aged, Preoperative Care, Retrospective Studies, Bile Duct Neoplasms surgery, Embolization, Therapeutic adverse effects, Klatskin Tumor surgery, Liver Failure etiology, Liver Neoplasms surgery, Portal Vein
Abstract

Background: Preoperative portal vein embolization (PVE) is frequently used to improve future liver remnant volume (FLRV) and to reduce the risk of liver failure after major liver resection., Objective: This paper aimed to assess postoperative outcomes after PVE and resection for suspected perihilar cholangiocarcinoma (PHC) in an international, multicentric cohort., Methods: Patients undergoing resection for suspected PHC across 20 centers worldwide, from the year 2000, were included. Liver failure, biliary leakage, and hemorrhage were classified according to the respective International Study Group of Liver Surgery criteria. Using propensity scoring, two equal cohorts were generated using matching parameters, i.e. age, sex, American Society of Anesthesiologists classification, jaundice, type of biliary drainage, baseline FLRV, resection type, and portal vein resection., Results: A total of 1667 patients were treated for suspected PHC during the study period. In 298 patients who underwent preoperative PVE, the overall incidence of liver failure and 90-day mortality was 27% and 18%, respectively, as opposed to 14% and 12%, respectively, in patients without PVE (p < 0.001 and p = 0.005). After propensity score matching, 98 patients were enrolled in each cohort, resulting in similar baseline and operative characteristics. Liver failure was lower in the PVE group (8% vs. 36%, p < 0.001), as was biliary leakage (10% vs. 35%, p < 0.01), intra-abdominal abscesses (19% vs. 34%, p = 0.01), and 90-day mortality (7% vs. 18%, p = 0.03)., Conclusion: PVE before major liver resection for PHC is associated with a lower incidence of liver failure, biliary leakage, abscess formation, and mortality. These results demonstrate the importance of PVE as an integral component in the surgical treatment of PHC.

Published
2020
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