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13 results on '"Lehmann, Kuno'

1. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal

Author

Eshmuminov, Dilmurodjon, Studer, Debora J., Lopez Lopez, Victor, Schneider, Marcel A., Lerut, Jan, Lo, Mary, Sher, Linda, Musholt, Thomas J., Lozan, Oana, Bouzakri, Nabila, Sposito, Carlo, Miceli, Rosalba, Barat, Shoma, Morris, David, Oehler, Helga, Schreckenbach, Teresa, Husen, Peri, Rosen, Charles B., Gores, Gregory J., Masui, Toshihiko, Cheung, Tan-To, Kim-Fuchs, Corina, Perren, Aurel, Dutkowski, Philipp, Petrowsky, Henrik, Thiis-Evensen, Espen, Line, Pål-Dag, Grat, Michal, Partelli, Stefano, Falconi, Massimo, Tanno, Lulu, Robles-Campos, Ricardo, Mazzaferro, Vincenzo, Clavien, Pierre-Alain, and Lehmann, Kuno

Published
2023
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2. Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin

Author

Schneider, Marcel André, Eden, Janina, Pache, Basile, Laminger, Felix, Lopez-Lopez, Victor, Steffen, Thomas, Hübner, Martin, Kober, Friedrich, Roka, Sebastian, Campos, Pedro Cascales, Roth, Lilian, Gupta, Anurag, Siebenhüner, Alexander, Kepenekian, Vahan, Passot, Guillaume, Gertsch, Philippe, Glehen, Olivier, and Lehmann, Kuno

Published
2018
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3. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis

Author

Eshmuminov, Dilmurodjon, primary, Studer, Debora J., additional, Lopez Lopez, Victor, additional, Schneider, Marcel A., additional, Lerut, Jan, additional, Lo, Mary, additional, Sher, Linda, additional, Musholt, Thomas J., additional, Lozan, Oana, additional, Bouzakri, Nabila, additional, Sposito, Carlo, additional, Miceli, Rosalba, additional, Barat, Shoma, additional, Morris, David, additional, Oehler, Helga, additional, Schreckenbach, Teresa, additional, Husen, Peri, additional, Rosen, Charles B., additional, Gores, Gregory J., additional, Masui, Toshihiko, additional, Cheung, Tan-To, additional, Kim-Fuchs, Corina, additional, Perren, Aurel, additional, Dutkowski, Philipp, additional, Petrowsky, Henrik, additional, Thiis-Evensen, Espen, additional, Line, Pål-Dag, additional, Grat, Michal, additional, Partelli, Stefano, additional, Falconi, Massimo, additional, Tanno, Lulu, additional, Robles-Campos, Ricardo, additional, Mazzaferro, Vincenzo, additional, Clavien, Pierre-Alain, additional, and Lehmann, Kuno, additional

Published
2022
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4. A Multicenter Randomized Clinical Trial of Primary Anastomosis or Hartmann's Procedure for Perforated Left Colonic Diverticulitis With Purulent or Fecal Peritonitis

Author

Stefan Breitenstein, Dimitri A. Raptis, Christian Buchli, Nicolas Demartines, Adrien A. Tempia-Caliera, Dieter Hahnloser, Hans Gelpke, Pierre-Alain Clavien, Kuno Lehmann, Andreas Rickenbacher, Felix Grieder, Peter M. Villiger, Marco Decurtins, Christian E. Oberkofler, University of Zurich, and Oberkofler, Christian Eugen

Subjects
Male, medicine.medical_specialty, Fecal peritonitis, Perforation (oil well), 610 Medicine & health, Peritonitis, Anastomosis, Statistics, Nonparametric, Diverticulitis, Colonic, law.invention, Postoperative Complications, Randomized controlled trial, law, medicine, Humans, Hartmann's procedure, 10217 Clinic for Visceral and Transplantation Surgery, Aged, Aged, 80 and over, Chi-Square Distribution, Ileostomy, business.industry, Primary anastomosis, Anastomosis, Surgical, Middle Aged, Diverticulitis, medicine.disease, 2746 Surgery, Surgery, Diverting ileostomy, Treatment Outcome, Intestinal Perforation, Female, business, Switzerland
Abstract

OBJECTIVES: : To evaluate the outcome after Hartmann's procedure (HP) versus primary anastomosis (PA) with diverting ileostomy for perforated left-sided diverticulitis. BACKGROUND: : The surgical management of left-sided colonic perforation with purulent or fecal peritonitis remains controversial. PA with ileostomy seems to be superior to HP; however, results in the literature are affected by a significant selection bias. No randomized clinical trial has yet compared the 2 procedures. METHODS: : Sixty-two patients with acute left-sided colonic perforation (Hinchey III and IV) from 4 centers were randomized to HP (n = 30) and to PA (with diverting ileostomy, n = 32), with a planned stoma reversal operation after 3 months in both groups. Data were analyzed on an intention-to-treat basis. The primary end point was the overall complication rate. The study was discontinued following an interim analysis that found significant differences of relevant secondary end points as well as a decreasing accrual rate (NCT01233713). RESULTS: : Patient demographics were equally distributed in both groups (Hinchey III: 76% vs 75% and Hinchey IV: 24% vs 25%, for HP vs PA, respectively). The overall complication rate for both resection and stoma reversal operations was comparable (80% vs 84%, P = 0.813). Although the outcome after the initial colon resection did not show any significant differences (mortality 13% vs 9% and morbidity 67% vs 75% in HP vs PA), the stoma reversal rate after PA with diverting ileostomy was higher (90% vs 57%, P = 0.005) and serious complications (Grades IIIb-IV: 0% vs 20%, P = 0.046), operating time (73 minutes vs 183 minutes, P < 0.001), hospital stay (6 days vs 9 days, P = 0.016), and lower in-hospital costs (US $16,717 vs US $24,014) were significantly reduced in the PA group. CONCLUSIONS: : This is the first randomized clinical trial favoring PA with diverting ileostomy over HP in patients with perforated diverticulitis.

Published
2012
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5. Reply to Letter

Author

Kuno Lehmann and Pierre-Alain Clavien

Subjects
medicine.medical_specialty, Chemotherapy, business.industry, General surgery, medicine.medical_treatment, Liver Neoplasms, Antineoplastic Agents, Resection, Surgery, medicine, Humans, Colorectal Neoplasms, business
Published
2015
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7. Mutations of RAS/RAFProto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin

Author

Schneider, Marcel André, Eden, Janina, Pache, Basile, Laminger, Felix, Lopez-Lopez, Victor, Steffen, Thomas, Hübner, Martin, Kober, Friedrich, Roka, Sebastian, Campos, Pedro Cascales, Roth, Lilian, Gupta, Anurag, Siebenhüner, Alexander, Kepenekian, Vahan, Passot, Guillaume, Gertsch, Philippe, Glehen, Olivier, and Lehmann, Kuno

Abstract

Supplemental Digital Content is available in the text

Published
2018
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8. New Insight Into Hyperthermic Intraperitoneal Chemotherapy

Author

Lehmann, Kuno, primary, Rickenbacher, Andreas, additional, Jang, Jae-Hwi, additional, Oberkofler, Christian E., additional, Vonlanthen, René, additional, von Boehmer, Lotta, additional, Humar, Bostjan, additional, Graf, Rolf, additional, Gertsch, Philippe, additional, and Clavien, Pierre-Alain, additional

Published
2012
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9. A Multicenter Randomized Clinical Trial of Primary Anastomosis or Hartmann's Procedure for Perforated Left Colonic Diverticulitis With Purulent or Fecal Peritonitis

Author

Oberkofler, Christian Eugen, primary, Rickenbacher, Andreas, additional, Raptis, Dimitri Aristotle, additional, Lehmann, Kuno, additional, Villiger, Peter, additional, Buchli, Christian, additional, Grieder, Felix, additional, Gelpke, Hans, additional, Decurtins, Marco, additional, Tempia-Caliera, Adrien A., additional, Demartines, Nicolas, additional, Hahnloser, Dieter, additional, Clavien, Pierre-Alain, additional, and Breitenstein, Stefan, additional

Published
2012
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11. Effects of Pentoxifylline on Liver Regeneration

Author

Petrowsky, Henrik, primary, Breitenstein, Stefan, additional, Slankamenac, Ksenija, additional, Vetter, Diana, additional, Lehmann, Kuno, additional, Heinrich, Stefan, additional, DeOliveira, Michelle L., additional, Jochum, Wolfram, additional, Weishaupt, Dominik, additional, Frauenfelder, Thomas, additional, Graf, Rolf, additional, and Clavien, Pierre-Alain, additional

Published
2010
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