1. Successful Arterial Substitution with Modified Human Umbilical Vein
- Author
-
Irving Dardik and Herbert Dardik
- Subjects
Umbilical Veins ,medicine.medical_specialty ,Polymers ,Inflammatory response ,Transplantation, Heterologous ,Umbilical vein ,chemistry.chemical_compound ,Transplantation Immunology ,medicine ,Animals ,Humans ,Transplantation, Homologous ,Dialdehyde starch ,Aneurysm formation ,Leg ,business.industry ,Capsule ,Arteries ,Haplorhini ,Surgical Mesh ,Surgery ,chemistry ,business ,Vascular graft ,Research Article ,Papio - Abstract
Human umbilical veins were prepared as vascular grafts by tanning with dialdehyde starch or gluteraldehyde and by structural re-inforcement with an outer polyester fiber mesh. These grafts were implanted in baboons in the aortoiliac position for periods of 3 days to 9 months. There was no aneurysm formation and there was an excellent maintenance of patency as well as function. Histologic evaluation of the graft materials showed a dense collagen layer within the encircling polyester fiber mesh. A multicellular subintimal layer formed a discrete inner capsule. The inflammatory response with the umbilical component was insignificant. There was no evidence of rejection. This study suggests that the modified umbilical vein can serve as a satisfactory blood conduit. Experience with three short-term clinical implants supports the applicability and potential for this new vascular graft.
- Published
- 1976