1. Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?
- Author
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Aamir Magzoub, Wed Ahmad Alaseeri, Iman Nasser, Ahmed Morad Asaad, Saeed Ali Alsareli, Alzahrani Mohammed Jamaan, Khalid Alshaybari, Dhafer Alshehri, Mohammed Helmy Faris Shalayel, Ahmed A. Mahfouz, Mohamed Ansar Qureshi, Mohammed Saeed Zayed Al-Ayed, and Hamdan Saad Alaamri
- Subjects
Leptin ,Male ,Pediatric Obesity ,Chemokine ,Adolescent ,Saudi Arabia ,lcsh:Medicine ,Adipokine ,030209 endocrinology & metabolism ,03 medical and health sciences ,Interleukin 21 ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Child ,Interleukin 5 ,Interleukin 4 ,Asthma ,biology ,business.industry ,Interleukins ,lcsh:R ,General Medicine ,medicine.disease ,Obesity ,Cross-Sectional Studies ,Immunology ,biology.protein ,Original Article ,Interleukin-4 ,Interleukin-5 ,business - Abstract
BACKGROUND: Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma. OBJECTIVES: Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma. DESIGN: Cross-sectional, analytical. SETTING: Population of schoolchildren in a small Saudi city. SUBJECTS AND METHODS: The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups. MAIN OUTCOME MEASURES: Serum levels of leptin, IL-4, IL-5, and IL-21. SAMPLE SIZE: 345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years. RESULTS: Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics (P
- Published
- 2019
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