1. A Histological, Immunological, and Electron Microscopic Study of Bovine Collagen Implants in the Human
- Author
-
Karen E. Burke, Gail Naughton, and Nick Cassai
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Bovine collagen ,Biopsy ,Fluorescent Antibody Technique ,Biocompatible Materials ,Immunofluorescence ,law.invention ,Dermis ,law ,medicine ,Animals ,Humans ,Electron microscopic ,Aged ,Skin ,Drug Implants ,Inflammation ,Microscopy ,biology ,medicine.diagnostic_test ,business.industry ,Microscopy, Electron ,medicine.anatomical_structure ,Immunoglobulin G ,biology.protein ,Cattle ,Surgery ,Collagen ,Implant ,Antibody ,Electron microscope ,business ,Subcutaneous tissue - Abstract
The histological fate of an injectable form of type I bovine dermal collagen (Zyderm collagen implant) in the human dermis and subcutaneous tissue has been studied. Sequential biopsies were analyzed by hematoxylin-eosin and Weigert's stains, by immunofluorescence (using a highly specific rabbit anti-Zyderm collagen antibody and a specific anti-human type III collagen antibody), and by electron miscroscopy. The results of this study suggest that the bovine implant material stimulates a host response resulting in implant degradation and replacement by newly generated host collagen.
- Published
- 1985