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Plants have always been a great source for human being by unveiling invaluable therapeutic activities due to the presence of various secondary metabolites and other chemicals present in them. The various parts of the plant are beneficial in offering pharmacological and other biological properties. The utility of these plants in - particular underground stems are proved to possess beneficial immunomodulatory effects and on altering the immune system by diverse mechanisms. In present scenario, COVID-19 has gone into danger stage, which poses a threat to every single person which is caused due to enhance globalization and ability of the coronavirus to get acclimatize at all conditions all over the globe. The unabated transmission of this deadly coronavirus is due to lacks of drugs to fight against this outbreak. But, attempts were made to formulate the vaccines and few countries have developed the vaccines mainly Russia, India and other countries. Through, vaccines and other modalities may help scientific communities to bring out a solution and are continuously striving to unravel the pharmacologically active compounds in all directions that might prove a new insight for curbing viral infections and pandemics. Hence. the COVID-19 scenario highlights an essential need for effective therapeutics against SARS-CoV-2. The present review discusses the role of underground stems as immunomodulators and vital concepts related to COVID-19 which tends to boost the immunity through immunomodulators from medicinal plants.