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Your search keyword '"Sousa, R"' showing total 22 results
Start Over Author "Sousa, R" Journal annals of oncology
22 results on '"Sousa, R"'

3. 285P Adherence to endocrine therapy and sexual dysfunction in patients older than 65 years with early estrogen receptor-positive breast cancer

Author

Assad, D.X., Santos, D.L. Dos, Resende, H.M., Moura, F. Cesar, Oliveira, S.C.S., Shimada, A.K., Arakelian, R., Galvão, A.L., Wance, B., Castro, A. Guimarães, Andrade, M.C.F.M.D., Rodrigues Beckedorff Bittencourt, Y. Cardoso, Magalhães, M.C.F., de Pádua Souza, C., Paiva, C.E., Signorini, P., Pereira, D.J., Rodrigues, A.N., Rosa, D.D., and Barroso-Sousa, R.

Published
2024
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4. 328TiP Phase III study of trastuzumab deruxtecan (T-DXd) with or without pertuzumab vs a taxane, trastuzumab and pertuzumab in first-line (1L), human epidermal growth factor receptor 2–positive (HER2+) metastatic breast cancer (mBC): DESTINY-Breast09

Author

Tolaney, S.M., primary, Barroso-Sousa, R., additional, Jiang, Z., additional, Park, Y.H., additional, Rimawi, M., additional, Saura Manich, C., additional, Schneeweiss, A., additional, Toi, M., additional, Yu, T., additional, Shetty, J., additional, Herbolsheimer, P., additional, and Loibl, S., additional

Published
2021
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5. 1320P Impact of body mass index (BMI) in non-small cell lung cancer patients treated with anti PD-1 immunotherapy (IO): A retrospective cohort study

Author

Bravo, A.C., primary, Lobo-Martins, S.L., additional, Vendrell, I., additional, Mansinho, A.B., additional, Melo-Alvim, C., additional, Hasmucrai, D., additional, Vilariça, A.S., additional, Alves, P., additional, Teixeira, E., additional, Teixeira de Sousa, R., additional, Bárbara, C., additional, and Costa, L., additional

Published
2020
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6. P-151 The impact of adjuvant chemotherapy regimens in stage II colon cancer (CC) patients

Author

Lobo-Martins, S., primary, Martins, M., additional, Semedo, P., additional, Alvim, C., additional, Pais, H. Luna, additional, Paiva, R., additional, Pinto, C., additional, Ribeiro, L., additional, Fernandes, I., additional, Macedo, D., additional, Mansinho, A., additional, Vendrell, I., additional, Sousa, R. Teixeira de, additional, and Costa, L., additional

Published
2020
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7. BRCA testing of 1,284 Brazilian patients for hereditary breast and ovarian cancer in a routine diagnostic setting

Author

Milanezi, F., primary, Silva, J.S., additional, de Marsillac, S.M., additional, Monfredini, P.M., additional, Nakano, V., additional, D’Andrea, M.G., additional, Guarischi-Sousa, R., additional, Schnabel, B., additional, Correia, W.D., additional, Campana, G.A., additional, da Fonseca, G.G., additional, Perrone, E., additional, and Zalcberg, I., additional

Published
2019
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8. immune profile of small HER2-positive breast cancers: a secondary analysis from the APT trial.

Author

Barroso-Sousa, R, Barry, W T, Guo, H, Dillon, D, Tan, Y B, Fuhrman, K, Osmani, W, Getz, A, Baltay, M, Dang, C, Yardley, D, Moy, B, Marcom, P K, Mittendorf, E A, Krop, I E, Winer, E P, and Tolaney, S M

Subjects
*HORMONE receptor positive breast cancer, *BREAST cancer, *EPIDERMAL growth factor receptors, *CLINICAL trial registries, *SECONDARY analysis, *BIOMARKERS
Abstract

Background Previous data suggest that the immune microenvironment plays a critical role in human epidermal growth factor receptor 2 (HER2) -positive breast cancer; however, there is little known about the immune profiles of small HER2-positive tumors. In this study, we aimed to characterize the immune microenvironment of small HER2-positive breast cancers included in the Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer (APT) trial and to correlate the immune markers with pathological and molecular tumor characteristics. Patients and methods The APT trial was a multicenter, single-arm, phase II study of paclitaxel and trastuzumab in patients with node-negative HER2-positive breast cancer. The study included 406 patients with HER2-positive, node-negative breast cancer, measuring up to 3 cm. Exploratory analysis of tumor infiltrating lymphocytes (TIL), programmed death-ligand 1 (PD-L1) expression (by immunohistochemistry), and immune gene signatures using data generated by nCounter PanCancer Pathways Panel (NanoString Technologies, Seattle, WA), and their association with pathological and molecular characteristics was carried out. Results Of the 406 patients, 328 (81%) had at least one immune assay carried out: 284 cases were evaluated for TIL, 266 for PD-L1, and 213 for immune gene signatures. High TIL (≥60%) were seen with greater frequency in hormone-receptor (HR) negative, histological grades 2 and 3, as well in HER2-enriched and basal-like tumors. Lower stromal PD-L1 (≤1%) expression was seen with greater frequency in HR-positive, histological grade 1, and in luminal tumors. Both TIL and stromal PD-L1 were positively correlated with 10 immune cell signatures, including Th1 and B cell signatures. Luminal B tumors were negatively correlated with those signatures. Significant correlation was seen among these immune markers; however, the magnitude of correlation did not indicate a monotonic relationship between them. Conclusion Immune profiles of small HER2-positive breast cancers differ according to HR status, histological grade, and molecular subtype. Further work is needed to explore the implication of these findings on disease outcome. Clinical trial registration clinicaltrials.gov identifier: NCT00542451. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Analysis of cancer outcomes after desensitization protocols in patients with metastatic disease

Author

Pulido, C., primary, Caiado, J., additional, Ferreira, A.R., additional, Vendrell, I., additional, Costa, A.L., additional, Mendes, A., additional, Pedro, M.E., additional, Fernandes, N., additional, Pestana, L., additional, Almeida, P.L., additional, Pinto, C., additional, Quintela, A., additional, Ribeiro, L., additional, Fernandes, I.C., additional, Filipe, P., additional, Sousa, R., additional, Abreu, C., additional, Macedo, D., additional, Barbosa, M.P., additional, and Costa, L.A.M., additional

Published
2016
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12. Non-Small Cell Lung Cancer'S Burden of Disease in Portugal

Author

Borges, M.F., primary, Gouveia, M., additional, Alarcão, J., additional, Sousa, R., additional, Barata, F., additional, Laranjeira, E., additional, Lopes, F., additional, Parente, B., additional, Pinheiro, L., additional, Teixeira, M.E., additional, Vaz-Carneiro, A., additional, and Costa, J., additional

Published
2014
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