2 results on '"Cadoni, G."'
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2. Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
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Stefania Boccia, Cristina Bosetti, Livia Petrelli, Rossana Verónica Mendoza López, Luca Giraldi, Gabriella Cadoni, Werner Garavello, Cristina Canova, Diego Serraino, Emanuele Leoncini, Mia Hashibe, Lorenzo Simonato, Lorenzo Richiardi, Victor Wünsch-Filho, Keitaro Matsuo, Paolo Boffetta, Dario Arzani, Jerry Polesel, Yuan Chin Amy Lee, M. B. de Carvalho, C. La Vecchia, Roberta Pastorino, Giraldi, L, Leoncini, E, Pastorino, R, Wunsch-Filho, V, de Carvalho, M, Lopez, R, Cadoni, G, Arzani, D, Petrelli, L, Matsuo, K, Bosetti, C, La Vecchia, C, Garavello, W, Polesel, J, Serraino, D, Simonato, L, Canova, C, Richiardi, L, Boffetta, P, Hashibe, M, Lee, Y, Boccia, S, and Giraldi, L. and Leoncini, E. and Pastorino, R. and Wünsch-Filho, V. and de Carvalho, M. and Lopez, R. and Cadoni, G. and Arzani, D. and Petrelli, L. and Matsuo, K. and Bosetti, C. and La Vecchia, C. and Garavello, W. and Polesel, J. and Serraino, D. and Simonato, L. and Canova, C. and Richiardi, L. and Boffetta, P. and Hashibe, M. and Lee, Y. and Boccia, S.
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Larynx ,Oncology ,Male ,Epidemiology ,0302 clinical medicine ,Japan ,Risk Factors ,cancer mortality ,030212 general & internal medicine ,Univariate analysis ,Prognostic factor ,Head and Neck Neoplasm ,adult ,international cooperation ,Hazard ratio ,Smoking ,drinking behavior ,Hematology ,Middle Aged ,hypopharynx cancer ,Prognosis ,educational statu ,3. Good health ,Europe ,Survival Rate ,Head and neck cancer ,Pooled analysis ,Prognostic factors ,Alcohol Drinking ,Female ,Follow-Up Studies ,Head and Neck Neoplasms ,Humans ,International Agencies ,Meta-Analysis as Topic ,medicine.anatomical_structure ,Italy ,priority journal ,Pooled analysi ,International Agencie ,030220 oncology & carcinogenesis ,meta analysis (topic) ,Settore MED/31 - OTORINOLARINGOIATRIA ,pooled analysis ,Brazil ,Human ,medicine.medical_specialty ,lifestyle ,Prognosi ,alcohol consumption ,overall survival ,cohort analysi ,cancer prognosi ,Article ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,medicine ,Carcinoma ,follow up ,Survival rate ,head and neck tumor ,business.industry ,cancer staging ,Risk Factor ,Cancer ,larynx cancer ,prognostic factors ,Original Articles ,medicine.disease ,mouth cancer ,oropharynx cancer ,major clinical study ,mortality ,cancer localization ,survival rate, Alcohol Drinking ,head and neck cancer ,business - Abstract
Background: This study evaluated whether demographics, pre-diagnosis lifestyle habits and clinical data are associated with the overall survival (OS) and head and neck cancer (HNC)-specific survival in patients with HNC. Patients and methods: We conducted a pooled analysis, including 4759 HNC patients from five studies within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cox proportional hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated including terms reported significantly associated with the survival in the univariate analysis. Results: Five-year OS was 51.4% for all HNC sites combined: 50.3% for oral cavity, 41.1% for oropharynx, 35.0% for hypopharynx and 63.9% for larynx. When we considered HNC-specific survival, 5-year survival rates were 57.4% for all HNC combined: 54.6% for oral cavity, 45.4% for oropharynx, 37.1% for hypopharynx and 72.3% for larynx. Older ages at diagnosis and advanced tumour staging were unfavourable predictors of OS and HNC-specific survival. In laryngeal cancer, low educational level was an unfavourable prognostic factor for OS (HR=2.54, 95% CI 1.01-6.38, for high school or lower versus college graduate), and status and intensity of alcohol drinking were prognostic factors both of the OS (current drinkers HR=1.73, 95% CI 1.16-2.58) and HNC-specific survival (current drinkers HR=2.11, 95% CI 1.22-3.66). In oropharyngeal cancer, smoking status was an independent prognostic factors for OS. Smoking intensity ( > 20 cigarettes/day HR=1.41, 95% CI 1.03-1.92) was also an independent prognostic factor for OS in patients with cancer of the oral cavity. Conclusions: OS and HNC-specific survival differ among HNC sites. Pre-diagnosis cigarette smoking is a prognostic factor of the OS for patients with cancer of the oral cavity and oropharynx, whereas pre-diagnosis alcohol drinking is a prognostic factor of OS and HNC-specific survival for patients with cancer of the larynx. Low educational level is an unfavourable prognostic factor for OS in laryngeal cancer patients. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
- Published
- 2017
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