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35 results on '"Bielack, S."'

1. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K Sundby, Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Gronchi, A., and Stacchiotti, S.

Published
2022
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2. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Author

Strauss, S.J., Frezza, A.M., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., de Álava, E., Dei Tos, A.P., Garcia del Muro, X., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Gaspar, N., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Gronchi, A., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., López Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Ladenstein, R., Casali, P.G., and Stacchiotti, S.

Published
2021
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3. Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

Author

Gronchi, A., Miah, A.B., Dei Tos, A.P., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., De Álava, E., Del Muro, X.G., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Casali, P.G., and Stacchiotti, S.

Published
2021
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4. Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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5. Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Bielack, S., Abecassis, N., Aro, H.T., Bauer, S., Biagini, R., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brennan, B., Brodowicz, T., Broto, J.M., Brugières, L., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Dhooge, C., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gaspar, N., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hassan, B., Hecker-Nolting, S., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kager, L., Kasper, B., Kopeckova, K., Krákorová, D.A., Ladenstein, R., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Morland, B., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Strauss, S.J., Sundby Hall, K., Unk, M., Van Coevorden, F., van der Graaf, W.T.A., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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6. Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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7. Osteosarcoma of the mobile spine

Author

Zils, K., Bielack, S., Wilhelm, M., Werner, M., Schwarz, R., Windhager, R., Hofmann-Wackersreuther, G., Andus, T., Kager, L., Kuehne, T., Reichardt, P., and von Kalle, T.

Published
2013
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11. 534P Larotrectinib in non-CNS TRK fusion cancer patients: Outcomes by prior therapy and performance status

Author

Drilon, A., primary, Shen, L., additional, van Tilburg, C.M., additional, Tan, D.S.W., additional, Kummar, S., additional, Lin, J.J., additional, Doz, F., additional, McDermott, R., additional, Albert, C.M., additional, Berlin, J., additional, Bielack, S., additional, Lassen, U.N., additional, Tahara, M., additional, Norenberg, R., additional, Fellous, M., additional, Nogai, H., additional, Xu, R., additional, Laetsch, T.W., additional, and Hong, D.S., additional

Published
2021
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14. EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment†

Author

Whelan, J. S., Bielack, S. S., Marina, N., Smeland, S., Jovic, G., Hook, J. M., Krailo, M., Anninga, J., Butterfass-Bahloul, T., Böhling, T., Calaminus, G., Capra, M., Deffenbaugh, C., Dhooge, C., Eriksson, M., Flanagan, A. M., Gelderblom, H., Goorin, A., Gorlick, R., Gosheger, G., Grimer, R. J., Hall, K. S., Helmke, K., Hogendoorn, P. C. W., Jundt, G., Kager, L., Kuehne, T., Lau, C. C., Letson, G. D., Meyer, J., Meyers, P. A., Morris, C., Mottl, H., Nadel, H., Nagarajan, R., Randall, R. L., Schomberg, P., Schwarz, R., Teot, L. A., Sydes, M. R., Bernstein, M., Pickering, James, Joffe, Nicola, Kevric, Matthias, Sorg, Benjamin, Villaluna, Doojduen, Wang, Caroline, Perisoglou, Martha, Trani, Leonardo, Potratz, Jenny, Carrle, Dorothe, Wilhelm, Miriam, Zils, Katja, and Teske, Carmen

Published
2015
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16. The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

Author

Andreou, D., Bielack, S. S., Carrle, D., Kevric, M., Kotz, R., Winkelmann, W., Jundt, G., Werner, M., Fehlberg, S., Kager, L., Kühne, T., Lang, S., Dominkus, M., Exner, G. U., Hardes, J., Hillmann, A., Ewerbeck, V., Heise, U., Reichardt, P., and Tunn, P. -U.

Published
2011
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22. EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment†

Author

Whelan, J. S., Bielack, S. S., Marina, N., Smeland, S., Jovic, G., Hook, J. M., Krailo, M., Anninga, J., Butterfass-Bahloul, T., Böhling, T., Calaminus, G., Capra, M., Deffenbaugh, C., Dhooge, C., Eriksson, M., Flanagan, A. M., Gelderblom, H., Goorin, A., Gorlick, R., Gosheger, G., Grimer, R. J., Hall, K. S., Helmke, K., Hogendoorn, P. C. W., Jundt, G., Kager, L., Kuehne, T., Lau, C. C., Letson, G. D., Meyer, J., Meyers, P. A., Morris, C., Mottl, H., Nadel, H., Nagarajan, R., Randall, R. L., Schomberg, P., Schwarz, R., Teot, L. A., Sydes, M. R., Bernstein, M., Pickering, James, Joffe, Nicola, Kevric, Matthias, Sorg, Benjamin, Villaluna, Doojduen, Wang, Caroline, Perisoglou, Martha, Trani, Leonardo, Potratz, Jenny, Carrle, Dorothe, Wilhelm, Miriam, Zils, Katja, and Teske, Carmen

Subjects
Male, Adolescent, Interferon-alpha, Sarcoma, Bone Neoplasms, Original Articles, Combined Modality Therapy, Neoadjuvant Therapy, Polyethylene Glycols, Young Adult, Methotrexate, Doxorubicin, Research Design, osteosarcoma, international collaboration, Antineoplastic Combined Chemotherapy Protocols, Quality of Life, Humans, Female, Ifosfamide, Cisplatin, Child, randomised controlled trial, trial conduct, Etoposide
Abstract

This manuscript describes the experience from registration until randomisation for a cohort of 2260 patients with osteosarcoma who joined the EURAMOS-1 trial. This includes pre-operative chemotherapy and surgery. It sets out the practical issues in collaboration and in achieving randomisation., Background Four international study groups undertook a large study in resectable osteosarcoma, which included two randomised controlled trials, to determine the effect on survival of changing post-operative chemotherapy based on histological response. Patients and methods Patients with resectable osteosarcoma aged ≤40 years were treated with the MAP regimen, comprising pre-operatively of two 5-week cycles of cisplatin 120 mg/m2, doxorubicin 75 mg/m2, methotrexate 12 g/m2 × 2 (MAP) and post-operatively two further cycles of MAP and two cycles of just MA. Patients were randomised after surgery. Those with ≥10% viable tumour in the resected specimen received MAP or MAP with ifosfamide and etoposide. Those with

Published
2014

23. Adolescents and young adults with cancer care in Asia: The joint ESMO/SIOPE/SIOP ASIA survey

Author

Dalvi, R., primary, Li, C.-K., additional, Yonemori, K., additional, Ariffin, H., additional, Lyu, C.J., additional, Farid, M., additional, Gonzales-Santos, J.R.N., additional, Zhou, Q., additional, Bielack, S., additional, Brugieres, L., additional, Blondeel, A., additional, Essiaf, S., additional, Peccatori, F.A., additional, Jezdic, S., additional, Stark, D., additional, Douillard, J.-Y., additional, Saloustros, E., additional, and Mountzios, G., additional

Published
2018
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24. Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach

Author

Tan, D.S.W., primary, Lassen, U.N., additional, Albert, C.M., additional, Kummar, S., additional, van Tilburg, C., additional, Dubois, S.G., additional, Geoerger, B., additional, Mascarenhas, L., additional, Federman, N., additional, Basu-Mallick, A., additional, Doz, F., additional, Berlin, J.D., additional, Oh, D.-Y., additional, Bielack, S., additional, McDermott, R., additional, Cruickshank, S., additional, Ku, N.C., additional, Cox, M.C., additional, Drilon, A., additional, and Hong, D.S., additional

Published
2018
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25. Corrections to “Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., primary, Abecassis, N., additional, Aro, H.T., additional, Bauer, S., additional, Biagini, R., additional, Bielack, S., additional, Bonvalot, S., additional, Boukovinas, I., additional, Bovee, J V M G, additional, Brodowicz, T., additional, Broto, J.M., additional, Buonadonna, A., additional, De Álava, E., additional, Dei Tos, A.P., additional, Del Muro, X.G., additional, Dileo, P., additional, Eriksson, M., additional, Fedenko, A., additional, Ferraresi, V., additional, Ferrari, A., additional, Ferrari, S., additional, Frezza, A.M., additional, Gasperoni, S., additional, Gelderblom, H., additional, Gil, T., additional, Grignani, G., additional, Gronchi, A., additional, Haas, R.L., additional, Hassan, B., additional, Hohenberger, P., additional, Issels, R., additional, Joensuu, H., additional, Jones, R.L., additional, Judson, I., additional, Jutte, P., additional, Kaal, S., additional, Kasper, B., additional, Kopeckova, K., additional, Krákorová, D.A., additional, Le Cesne, A., additional, Lugowska, I., additional, Merimsky, O., additional, Montemurro, M., additional, Pantaleo, M.A., additional, Piana, R., additional, Picci, P., additional, Piperno-Neumann, S., additional, Pousa, A.L., additional, Reichardt, P., additional, Robinson, M.H., additional, Rutkowski, P., additional, Safwat, A.A., additional, Schöffski, P., additional, Sleijfer, S., additional, Stacchiotti, S., additional, Sundby Hall, K., additional, Unk, M., additional, Van Coevorden, F., additional, van der Graaf, W.T.A., additional, Whelan, J., additional, Wardelmann, E., additional, Zaikova, O., additional, and Blay, J.Y., additional

Published
2018
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26. Corrections to “Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., primary, Abecassis, N., additional, Aro, H.T., additional, Bauer, S., additional, Biagini, R., additional, Bielack, S., additional, Bonvalot, S., additional, Boukovinas, I., additional, Bovee, J V M G, additional, Brodowicz, T., additional, Broto, J.M., additional, Buonadonna, A., additional, De Álava, E., additional, Dei Tos, A.P., additional, Del Muro, X.G., additional, Dileo, P., additional, Eriksson, M., additional, Fedenko, A., additional, Ferraresi, V., additional, Ferrari, A., additional, Ferrari, S., additional, Frezza, A.M., additional, Gasperoni, S., additional, Gelderblom, H., additional, Gil, T., additional, Grignani, G., additional, Gronchi, A., additional, Haas, R.L., additional, Hassan, B., additional, Hohenberger, P., additional, Issels, R., additional, Joensuu, H., additional, Jones, R.L., additional, Judson, I., additional, Jutte, P., additional, Kaal, S., additional, Kasper, B., additional, Kopeckova, K., additional, Krákorová, D.A., additional, Le Cesne, A., additional, Lugowska, I., additional, Merimsky, O., additional, Montemurro, M., additional, Pantaleo, M.A., additional, Piana, R., additional, Picci, P., additional, Piperno-Neumann, S., additional, Pousa, A.L., additional, Reichardt, P., additional, Robinson, M.H., additional, Rutkowski, P., additional, Safwat, A.A., additional, Schöffski, P., additional, Sleijfer, S., additional, Stacchiotti, S., additional, Sundby Hall, K., additional, Unk, M., additional, Van Coevorden, F., additional, van der Graaf, W.T.A., additional, Whelan, J., additional, Wardelmann, E., additional, Zaikova, O., additional, and Blay, J.Y., additional

Published
2018
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28. Phase 1/2 study of the selective TRK inhibitor larotrectinib, in pediatric patients with cancer

Author

Gallego Mélcon, S., primary, Casanova, M., additional, Bielack, S., additional, Chisholm, J., additional, van Tilburg, C.S., additional, Federman, N., additional, Albert, C.M., additional, Mascarenhas, L., additional, Turpin, B., additional, Nagasubramanian, R., additional, Shukla, N., additional, Spunt, S., additional, Cox, M.C., additional, Hawkins, D.S., additional, Pappo, A.S., additional, Doz, F., additional, Bisogno, G., additional, Dubois, S.G., additional, Laetsch, T.W., additional, and Geoerger, B., additional

Published
2017
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29. Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.

Author

Bielack, S S, Cox, M C, Nathrath, M, Apel, K, Blattmann, C, Holl, T, Jenewein, R, Klenk, U, Klothaki, P, Müller-Abt, P, Ortega-Lawerenz, S, Reynolds, M, Scheer, M, Simon-Klingenstein, K, Stegmaier, S, Tupper, R, Vokuhl, C, and Kalle, T von

Subjects
*GENE fusion, *FIBROSARCOMA, *TUMORS, *MAGNETIC resonance imaging, *INFANTS, *VINCRISTINE
Abstract

Background The ETV6-NTRK3 gene fusion is present in the majority of cases of infantile fibrosarcoma (IFS) and acts as a potent oncogenic driver. We report the very rapid, complete, and sustained response of an advanced, chemotherapy-refractory, recurrent IFS to targeted treatment with the oral tropomyosin receptor kinase (TRK) inhibitor larotrectinib. Patient and methods A male infant born with a large congenital IFS of the tongue had the tumour surgically resected at age 4 days. Within 2 months, he developed extensive lymph node recurrence that progressed during two cycles of vincristine-doxorubicin-cyclophosphamide chemotherapy. At screening, a large right cervical mass was clinically visible. Magnetic resonance imaging (MRI) revealed bilateral cervical and axillary lymph node involvement as well as infiltration of the floor of the mouth. The largest lesion measured 5.5×4.5×4.4 cm (ca. 55 cm3). The patient started outpatient oral larotrectinib at 20 mg/kg twice daily at age 3.5 months. Results After 4 days on treatment, the parents noted that the index tumour was visibly smaller and softer. The rapid tumour regression continued over the following weeks. On day 56 of treatment, the first scheduled control MRI showed the target lesion had shrunk to 1.2×1.2×0.8 cm (ca. 0.6 cm3), corresponding to a complete response according to the Response Evaluation Criteria In Solid Tumors version 1.1. This response was maintained over subsequent follow-up visits, and on day 112 at the second control MRI the target lymph node was completely normal. At last follow-up, the disease remained in complete remission after 16 months on larotrectinib, with negligible toxicity and no safety concerns. Conclusion(s) Selective TRK inhibition by larotrectinib offers a novel, highly specific and highly effective therapeutic option for IFS carrying the characteristic ETV6-NTRK3 gene fusion. Its use should be considered when surgery is not feasible. (NCT02637687) [ABSTRACT FROM AUTHOR]

Published
2019
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32. High-grade bone sarcomas with synchronous metastases in patients older than 40. Results of the European Bone over 40: Sarcoma Study (EURO.B.O.S.S.)

Author

Cesari, M., primary, Comandone, A., additional, Boglione, A., additional, Ferraresi, V., additional, Bertulli, R., additional, Bielack, S., additional, Sundby Hall, K., additional, Rocca, M., additional, Donati, D., additional, Palmerini, E., additional, Paioli, A., additional, Longhi, A., additional, Gambarotti, M., additional, Righi, A., additional, Picci, P., additional, and Ferrari, S., additional

Published
2015
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