1. The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile.
- Author
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Semmler A, Farmand S, Moskau S, Stoffel-Wagner B, and Linnebank M
- Subjects
- Adult, Aged, Cerebrovascular Disorders physiopathology, Cholesterol, HDL blood, Cholesterol, LDL blood, Female, Genotype, Homocysteine blood, Homocysteine metabolism, Humans, Lipoproteins metabolism, Male, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Methylenetetrahydrofolate Reductase (NADPH2) metabolism, Middle Aged, Polymorphism, Genetic, Reduced Folate Carrier Protein metabolism, Transcobalamins metabolism, White People, Alleles, Lipoproteins blood, Transcobalamins genetics
- Abstract
Background/aim: Recent studies have suggested a relation of homocysteine with lipid metabolism. The aim of this study was to analyze a possible genetic basis for such a relation in 504 individuals including 135 consecutive Caucasian patients diagnosed with cerebrovascular disease as well as the patients' healthy spouses (n = 100) and offspring (n = 269)., Methods: We analyzed the association of plasma levels of lipoprotein(a), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides with plasma homocysteine levels and with the following 7 variants of homocysteine metabolism: dihydrofolate reductase c.594 + 59del19bp, cystathionine β-synthase c.844_855ins68, methionine synthase c.2756A→G, methylenetetrahydrofolate reductase c.677C→T and c.1298A→C, reduced folate carrier 1 c.80G→A, and transcobalamin 2 (Tc2) c.776C→G., Results: Linear regression analysis showed an association of Tc2 c.776C→G with LDL (p = 0.010), HDL (p = 0.009), and TG (p = 0.007), with the G allele of Tc2 c.776C→G associated with an unfavorable blood lipid profile. Moreover, the G allele of Tc2 c.776C→G was associated with higher homocysteine plasma levels in the subgroup of patients (p = 0.013, 1-way ANOVA)., Conclusion: These data support the hypothesis that alterations in homocysteine metabolism and an unfavorable blood lipoprotein profile may have a common genetic basis. Such conditions may be relevant for studies investigating independent risk factors for vascular disease., (Copyright © 2010 S. Karger AG, Basel.)
- Published
- 2010
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