1. Body Composition in Diabetic Subjects with Chronic Kidney Disease: Interest of Bio-Impedance Analysis, and Anthropometry
- Author
-
Philippe Chauveau, C. Lasseur, C. Combe, L. Baillet-Blanco, Caroline Perlemoine, N. Barthes, Vincent Rigalleau, Henri Gin, and Christelle Raffaitin
- Subjects
Male ,medicine.medical_specialty ,Urology ,Medicine (miscellaneous) ,Renal function ,urologic and male genital diseases ,Diabetic nephropathy ,Predictive Value of Tests ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Electric Impedance ,medicine ,Humans ,Diabetic Nephropathies ,Muscle, Skeletal ,Uremia ,Nutrition and Dietetics ,Anthropometry ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Endocrinology ,Body Composition ,Lean body mass ,Kidney Failure, Chronic ,Female ,business ,Bioelectrical impedance analysis ,Glomerular Filtration Rate ,Kidney disease - Abstract
Background/Aims: Lean body mass (LBM) is reduced in uremia, but this has not been reported in diabetic nephropathy. Subjects and Methods: We compared predicted % LBM to DEXA measurements in 10 non-diabetic uremic, 10 non-uremic diabetic and 10 uremic diabetic subjects matched for age, gender and BMI. We also measured % LBM by anthropometry, bio-impedance analysis (BIA) and compared them with DEXA in 49 diabetic subjects with a wide range of renal failure. The results were compared and a Bland & Altman procedure was performed. Associations between glomerular filtration rate (GFR) and % LBM were tested. Results: In matched groups, predicted % LBM values were overestimated in non-diabetic uremic subjects, and underestimated in non-uremic diabetic subjects. In uremic diabetic subjects, the error was intermediary. As compared to DEXA (% LBM: 69.0 ± 7.1%), measurement of % LBM by anthropometry (71.4 ± 8.0%, p < 0.05) and BIA (67.2 ± 7.6%, p < 0.05) were biased in the 49 diabetic subjects. The mean of anthropometric and BIA (Ant+BIA) were similar to DEXA results (69.3 ± 6.8%, p = 0.64), with best correlation coefficients and Bland & Altman plots. GFR was correlated to % LBM assessed by DEXA, BIA and Ant+BIA. Conclusion: In diabetic subjects with chronic kidney disease, LBM should be measured, rather than predicted. A good evaluation is possible, even without DEXA.
- Published
- 2004
- Full Text
- View/download PDF