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Your search keyword '"Jager, Philip L De"' showing total 2 results
Start Over Author "Jager, Philip L De" Journal annals of neurology
2 results on '"Jager, Philip L De"'

1. Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk

Author

Xia, Zongqi, primary, White, Charles C., additional, Owen, Emily K., additional, Korff, Alina Von, additional, Clarkson, Sarah R., additional, McCabe, Cristin A., additional, Cimpean, Maria, additional, Winn, Phoebe A., additional, Hoesing, Ashley, additional, Steele, Sonya U., additional, Cortese, Irene C. M., additional, Chitnis, Tanuja, additional, Weiner, Howard L., additional, Reich, Daniel S., additional, Chibnik, Lori B., additional, and Jager, Philip L. De, additional

Published
2015
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2. Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.

Author

Xia, Zongqi, White, Charles C., Owen, Emily K., Korff, Alina Von, Clarkson, Sarah R., McCabe, Cristin A., Cimpean, Maria, Winn, Phoebe A., Hoesing, Ashley, Steele, Sonya U., Cortese, Irene C. M., Chitnis, Tanuja, Weiner, Howard L., Reich, Daniel S., Chibnik, Lori B., Jager, Philip L. De, Von Korff, Alina, and De Jager, Philip L

Subjects
DISEASE susceptibility, ECOLOGY, FAMILIES, GENETIC polymorphisms, LONGITUDINAL method, MULTIPLE sclerosis, RESEARCH funding, RISK assessment, DISEASE incidence
Abstract

The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects. [ABSTRACT FROM AUTHOR]

Published
2016
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