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Background To evaluate the use of allogenic freeze-dry PRP for the full-thickness wound healing process in experimental animals (rabbits). Material and methods This study is an experimental research using the posttest-only design, a simple randomized design. Thirty rabbits were randomly divided into six groups (three control groups and three treatment groups), and each group consisted of five subjects. Skin-thick cuts were made on the back of each rabbit. Wounds in the control group were treated using a paraffin gauze, and allogenic freeze-dried PRP was given to the treatment group; observations were made on the 3rd, 9th, and 14th days. The t-test on two random samples and Mann–Whitney were used to process data. The results were significant at p, Highlights • There were significant differences in the average number of fibroblasts in the control groups and the treatment groups. • There were major differences in the average amount of neovascularization between the control group and the treatment group. • Allogenic freeze-dried PRP could increase the number of fibroblasts and neovascularization in wound healing.