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Swelling of the parotid region is a frequent reason for consultation and the first clinical sign of both benign and malignant parotid tumors. These parotid tumors represent 80 % of tumors of the main salivary glands. They present a highly variable clinical and radiological picture and are known to have a wide histological diversity. Some histological types are rare entities found in the parotid gland, such as Ewing's sarcoma and lymphoepithelial cyst, the latter of which is often associated with HIV co-morbidity, and therefore requires careful and adequate therapeutic attitudes and strategies. We report two cases of parotid swelling revealing unusual pathologies: HIV and Ewing's sarcoma., Highlights • Swelling of the parotid region is a frequent reason for consultation. • Some histological types are rare entities found in the parotid gland. • The pathological examination of the surgical specimen provides a definitive diagnosis. • Age can be a concealing element, therefore a careful medical attitude is the key.

Tumors of the retromolar trigone area represent 12% of neoplasms of the oral cavity, and of which squamous cell carcinoma represents the main histological type. Mucoepidermoid carcinoma (MEC) of the accessory salivary glands is a rare entity, representing less than 5% of head and neck cancers, and 10% of all salivary gland tumors; its biological characteristics are very diverse, correlated to the histological grade of the tumor. This tumor has an excellent outcome after surgical management, with a prognosis related to the histological grade of the tumor. The authors reported a case of low-grade mucoepidermoid carcinoma, arising in the left retromolar trigon, in an 83-year-old woman who was treated by surgical removal of the tumor with a 1.5 cm border., Highlights • Mucoepidermoid carcinoma (MEC) of the accessory salivary glands is a rare entity. • Its biological characteristics are very diverse, correlated to the histological grade of the tumor. • This tumor has an excellent outcome after surgical management; with a prognosis related to the histological grade of the tumor. • We reported a case of low-grade mucoepidermoid carcinoma, arising in the left retromolar trigon, in an 83-year-old woman, treated by surgical resection.

Ameloblastomas are quite frequent odontogenic tumors, they can be intraosseous or peripheral to the gum, it's rare to find an intraosseous ameloblastoma with gingival extension. Here, we report the case of a 40 years old woman who presented with an exophytic gingival lesion at the gum level of the 46 tooth that was extracted at a quack 01 years before her consultation due to pain in this area. Clinical and radiological examination revealed the presence of two tumors in the same area. The patient benefited from an excision of her gingival tumor and an enucleation of her intraosseous tumor. Histopathological and immunohistochemical examinations revealed that the respective tumors were a spindle cell epulis and an intraluminal unicystic ameloblastoma of different origins, leaving the question and search for the relationship between these two tumors. The postoperative course was uneventful during the 12-month follow-up period after surgical treatment., Highlights • Ameloblastoma is a fairly rare tumor that can be intraosseous or peripheral. • It is rare to find a peripheral ameloblastoma that reaches the bone or an intraosseous ameloblastoma that extends to the gum. • The occurrence of two tumors in the same anatomical region, makes one wonder about the relationship between the two.

Introduction The parotid gland is a very rare location of Ewing's sarcoma. Its clinical and radiological manifestations are atypical. Its management is based on a multidisciplinary approach to improve prognosis and survival. Discussion The diagnosis of parotid Ewing's sarcoma is determined by a combination of genetic and histological criteria. Its local aggressiveness and high metastatic potential require prompt and appropriate management. Many prognostic features affect its management, the most important is the TNM staging. Conclusion Limited cases of parotid Ewing's sarcoma have been published in the literature. This small number of reported cases is the only way to study its characteristics., Highlights • The parotid gland is a very rare location of Ewing's sarcoma. • The diagnosis of parotid Ewing's sarcoma is determined by a combination of genetic and histological criteria. • Many prognosis features affect its management, the most important is the TNM staging.