1. Diversity of heart failure phenotypes in transthyretin amyloid cardiomyopathy. More than just heart failure with preserved ejection fraction
- Author
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Anouk Achten, Steven A. Muller, Sandra Sanders-van Wijk, Manon G. van der Meer, Pim van der Harst, Peter van Tintelen, Anneline SJM te Riele, Vanessa van Empel, Marish IFJ Oerlemans, and Christian Knackstedt
- Subjects
Transthyretin cardiac amyloidosis ,Echocardiography ,diagnostic guidelines ,heart failure ,left ventricular dilatation ,Medicine - Abstract
Introduction Current guidelines recommend suspecting transthyretin amyloid cardiomyopathy (ATTR-CM) in patients over 65 years of age with unexplained left ventricular (LV) hypertrophy in a non-dilated LV, heart failure (HF) and preserved ejection fraction (HFpEF), hypertrophic cardiomyopathy or severe aortic stenosis. However, there is evidence indicating a high prevalence of ATTR-CM in other HF phenotypes. As such, this study aimed to characterize the diversity of HF phenotypes of ATTR-CM by examining the LV ejection fraction and LV dilatation using echocardiography.Methods This multicentre, retrospective observational study included patients diagnosed with ATTR-CM between 2015–2023. The diagnosis was based on a positive cardiac biopsy or positive bone scintigraphy without monoclonal gammopathy. Echocardiographic measurements were categorized according to LV ejection fraction (LVEF) into HFpEF (LVEF ≥50%), HF with mildly reduced EF (HFmrEF, LVEF 40–49%), and HF with reduced EF (HFrEF, LVEF
- Published
- 2024
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