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Your search keyword '"Järvinen, Otso"' showing total 4 results
Start Over Author "Järvinen, Otso" Journal annals of medicine
4 results on '"Järvinen, Otso"'

1. Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study

Author

Niinisalo, Petri, primary, Oksala, Niku, additional, Levula, Mari, additional, Pelto-Huikko, Markku, additional, Järvinen, Otso, additional, Salenius, Juha-Pekka, additional, Kytömäki, Leena, additional, Soini, Juhani T., additional, Kähönen, Mika, additional, Laaksonen, Reijo, additional, Hurme, Mikko, additional, and Lehtimäki, Terho, additional

Published
2009
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2. ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries—Tampere vascular study

Author

Oksala, Niku, primary, Levula, Mari, additional, Airla, Nina, additional, Pelto-Huikko, Markku, additional, Ortiz, Rebekka M., additional, Järvinen, Otso, additional, Salenius, Juha-Pekka, additional, Ozsait, Bilge, additional, Komurcu-Bayrak, Evrim, additional, Erginel-Unaltuna, Nihan, additional, Huovila, Ari-Pekka J., additional, Kytömäki, Leena, additional, Soini, Juhani T., additional, Kähönen, Mika, additional, Karhunen, Pekka J., additional, Laaksonen, Reijo, additional, and Lehtimäki, Terho, additional

Published
2009
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3. ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study

Author

Levula, Mari, primary, Airla, Niku, additional, Oksala, Niku, additional, Hernesniemi, Jussi A., additional, Pelto-Huikko, Markku, additional, Salenius, Juha-Pekka, additional, Zeitlin, Rainer, additional, Järvinen, Otso, additional, Huovila, Ari-Pekka J., additional, Nikkari, Seppo T., additional, Jaakkola, Olli, additional, Ilveskoski, Erkki, additional, Mikkelsson, Jussi, additional, Perola, Markus, additional, Laaksonen, Reijo, additional, Kytömäki, Leena, additional, Soini, Juhani T., additional, Kähönen, Mika, additional, Parkkinen, Jyrki, additional, Karhunen, Pekka J., additional, and Lehtimäki, Terho, additional

Published
2009
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4. Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study.

Author

Niinisalo, Petri, Oksala, Niku, Levula, Mari, Pelto-Huikko, Markku, Järvinen, Otso, Salenius, Juha-Pekka, Kytömäki, Leena, Soini, Juhani T., Kähönen, Mika, Laaksonen, Reijo, Hurme, Mikko, and Lehtimäki, Terho

Abstract

Objective. We aimed to characterize the expression of indoleamine 2,3-dioxygenase (IDO) or IDO-induced tryptophan degradation-dependent pathways, which may lead to suppression of T cells and possible protection against atherosclerosis. Methods and results. Expression of IDO and IDO-related pathway components was analyzed in advanced human atherosclerotic plaques ( n = 24) and in non-atherosclerotic arteries ( n = 6). Up-regulation of IDO and genes related to the IDO pathway was found to be pronounced in atherosclerotic plaques. Immunohistochemistry demonstrated IDO protein in the atheromatous core and co-distribution with monocyte-macrophages (CD68-positive cells). In gene-set enrichment analysis, the IDO pathway revealed a significant (false discovery rate (FDR) = 0.07) regulatory T cell, fork-head box protein 3 (FoxP3)-initiated CD28-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-inducible T cell co-stimulator (ICOS)-driven pathway leading to activation of IDO expression in antigen-presenting cells (APCs). Expression of these IDO pathway genes varied between 2.1- and 16.8-fold as compared to control tissues ( P < 0.05 for all). Conclusions. IDO and the IDO-related pathway are important mediators of the immunoinflammatory responses in advanced atherosclerosis offering new viable therapeutic targets for the development of antiatherogenic immunosuppressive therapies. [ABSTRACT FROM AUTHOR]

Published
2010
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