1. Increased Gastric pH and the Bioavailability of Fluconazole and Ketoconazole
- Author
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Harvey R. Goldstein, John H. Wilton, Eugenia B. Henry, Jerome J. Schentag, Becky M. Florentino, Mark J. Gardner, Donald M. Hilligoss, David T. D'andrea, and Robert A. Blum
- Subjects
Adult ,Male ,medicine.medical_specialty ,Statistics as Topic ,Biological Availability ,Absorption (skin) ,Pharmacology ,Achlorhydria ,Random Allocation ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Drug Interactions ,Fluconazole ,Gastric Acidity Determination ,business.industry ,General Medicine ,medicine.disease ,Bioavailability ,Gastric ph ,Ketoconazole ,Endocrinology ,Orally active ,Cimetidine ,business ,medicine.drug - Abstract
Two orally active antifungal agents are currently available, ketoconazole and fluconazole. However, the absorption of ketoconazole depends on gastric pH for tablet disintegration and dissolution (1...
- Published
- 1991
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