1. Home remodeling and risk of childhood leukemia.
- Author
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Whitehead TP, Adhatamsoontra P, Wang Y, Arcolin E, Sender L, Selvin S, and Metayer C
- Subjects
- Adolescent, California, Case-Control Studies, Child, Child, Preschool, Ethnicity statistics & numerical data, Female, Humans, Infant, Logistic Models, Male, Odds Ratio, Risk Factors, Air Pollution, Indoor adverse effects, Air Pollution, Indoor statistics & numerical data, Construction Materials adverse effects, Environmental Exposure adverse effects, Environmental Exposure statistics & numerical data, Leukemia, Myeloid, Acute etiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma etiology
- Abstract
Purpose: We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures., Methods: We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995-2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weatherproofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility., Results: Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (odds ratio [OR]: 1.52, 95% confidence interval [CI]: 1.14-2.02) and a nonsignificant increase in AML risk (OR: 1.75, 95% CI: 0.98-3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04-2.07)., Conclusions: Specific home remodeling activities appeared to be associated with increased risk of childhood ALL., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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