1. Corneal nerve loss predicts dementia in patients with mild cognitive impairment
- Author
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Georgios Ponirakis, Hanadi Al Hamad, Dunya A. M. Omar, Ioannis N. Petropoulos, Adnan Khan, Hoda Gad, Mani Chandran, Masharig Gadelseed, Ahmed Elsotouhy, Marwan Ramadan, Priya V. Gawhale, Marwa Elorrabi, Rhia Tosino, Ziyad R. Mahfoud, Shafi Khan, Pravija Manikoth, Yasmin H. M. Abdelrahim, Mahmoud A. Refaee, Noushad Thodi, Ahmed Own, Ashfaq Shuaib, and Rayaz A. Malik
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objectives This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). Methods Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. Results Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p
- Published
- 2023
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