1. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease
- Author
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Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, Hongbo Luo, Brian A. Gordon, Timothy R. Holden, Nigel J. Cairns, Erin E. Franklin, Charles D. Chen, Yan Li, Richard J. Perrin, Beau M. Ances, and Dean W. Coble
- Subjects
0301 basic medicine ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Tau pathology ,Late onset ,Total tau ,tau Proteins ,Disease ,Neuropil thread ,Brief Communication ,Tangle ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Parietal Lobe ,mental disorders ,medicine ,Humans ,Senile plaques ,Age of Onset ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Middle Aged ,Frontal Lobe ,030104 developmental biology ,Positron emission tomography ,Positron-Emission Tomography ,Female ,Neurology (clinical) ,Autopsy ,Radiopharmaceuticals ,business ,Brief Communications ,030217 neurology & neurosurgery ,Carbolines - Abstract
Antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late‐onset Alzheimer’s disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. Here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late‐onset Alzheimer’s disease, autosomal dominant Alzheimer’s disease showed even greater tangle and thread burdens. Regional tau burden resembled that observed in tau imaging of a separate cohort at earlier clinical stages. Finally, our results suggest tau imaging measures total tau burden in Alzheimer’s disease, composed predominantly of tangle and thread pathology.
- Published
- 2020