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Your search keyword '"Kristine M. Fischenich"' showing total 2 results
Start Over "Kristine M. Fischenich" Journal annals of biomedical engineering
2 results on '"Kristine M. Fischenich"'

1. The Effect of Anterior Cruciate Ligament Reconstruction with an Electropsun Scaffold on Tibiofemoral Contact Mechanics

Author

Tammy L. Haut Donahue, Jeremiah T. Easley, Kristine M. Fischenich, Ketul C. Popat, Hannah M. Pauly, Daniel J. Kelly, and Ross H. Palmer

Subjects
Scaffold, Materials science, Tissue engineered, Anterior cruciate ligament reconstruction, musculoskeletal, neural, and ocular physiology, medicine.medical_treatment, Anterior cruciate ligament, Biomedical Engineering, Soft tissue graft, musculoskeletal system, surgical procedures, operative, Contact mechanics, medicine.anatomical_structure, Cadaver, medicine, human activities, Contact pressure, Biomedical engineering
Abstract

Surgical reconstruction of the torn ACL is performed to restore native contact mechanics. Drawbacks to traditional ACL repair techniques motivate the development of a tissue engineered ACL scaffold. Our group has developed a hierarchical electrospun polycaprolactone (PCL) scaffold that consists of rolled nanofiber bundles attached at each end with solvent-case blocks of PCL. The goal of this study was to compare ovine cadaver tibiofemoral contact mechanics after ACL reconstruction with the electrospun scaffold to a clinically applicable ACL reconstruction with a soft tissue graft and the ACL transected condition (ACLX). In the ACLX group and after ACL reconstruction with either the electrospun scaffold or soft tissue graft, pressure sensors were inserted under the menisci. Loads up to 890 N were applied at various flexion angles. The scaffold performed the best at restoring contact mechanics in the medial hemijoint to that of the native ACL. The scaffold was good at maintaining a medial-lateral balance of pressures as in the native joint whereas the ACLX shifted pressure off the lateral and on to the medial hemijoint. While the ACL scaffold didn't restore mechanics to that of the native condition, it improved contact mechanics compared to the standard graft replacement and ACLX condition.

Published
2021
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2. A Hydrogel Meniscal Replacement: Knee Joint Pressure and Distribution in an Ovine Model Compared to Native Tissue.

Author

Fischenich, Kristine M., Pauly, Hannah M., Lewis, Jackson T., Bailey, Travis S., and Haut Donahue, Tammy L.

Abstract

Pressure distribution of the native ovine knee meniscus was compared to a medial meniscectomy and three treatment conditions including a suture reattachment of the native tissue, an allograft, and a novel thermoplastic elastomer hydrogel (TPE) construct. The objective of this study was to assess the efficacy of a novel TPE hydrogel construct at restoring joint pressure and distribution. Limbs were loaded in uniaxial compression at 45°, 60°, and 75° flexion and from 0 to 181 kg. The medial meniscectomy decreased contact area by approximately 50% and doubled the mean and maximum pressure reading for the medial hemijoint. No treatment condition tested within this study was able to fully restore medial joint contact area and pressures to the native condition. A decrease in lateral contact area and increase in pressures with the meniscectomy was also seen; and to some degree, all reattachment and replacement conditions including the novel TPE hydrogel replacement helped to restore lateral pressures. Although the TPE construct did not perform as well as hoped in the medial compartment, it performed as well as, if not better, than the other reattachment and replacement options in the lateral. Further work is necessary to determine the best anchoring and attachment methods. [ABSTRACT FROM AUTHOR]

Published
2018
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