1. Salivary Cortisol and Cold Pain Sensitivity in Female Twins
- Author
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Godfrey, Kathryn M, Strachan, Eric, Dansie, Elizabeth, Crofford, Leslie J, Buchwald, Dedra, Goldberg, Jack, Poeschla, Brian, Succop, Annemarie, Noonan, Carolyn, and Afari, Niloofar
- Subjects
Health Sciences ,Chronic Pain ,Neurosciences ,Genetics ,Clinical Research ,Pain Research ,2.1 Biological and endogenous factors ,Aetiology ,Adolescent ,Adult ,Cold Temperature ,Female ,Humans ,Hydrocortisone ,Hypothalamo-Hypophyseal System ,Pain ,Pain Measurement ,Pain Threshold ,Pituitary-Adrenal System ,Saliva ,Twins ,Young Adult ,Cortisol ,Cold pressor ,Medical and Health Sciences ,Education ,Psychology and Cognitive Sciences ,Public Health ,Health sciences ,Psychology - Abstract
BackgroundThere is a dearth of knowledge about the link between cortisol and pain sensitivity.PurposeWe examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.MethodsThree-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.ResultsLower diurnal variation of cortisol was associated with higher pain ratings at threshold (p = 0.02) and tolerance (p
- Published
- 2014