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1. [Experimental research on the use of deferoxamine in the prevention of renal damage from acute ischemia].

Author

Libra S, Pagano D, Curella G, Litrico V, Cancelliere M, Audibert D, La Terra S, Gruttadauria S, Pappalardo A, and D'Alessandro M

Subjects
Acute Disease, Analysis of Variance, Animals, Drug Evaluation, Preclinical, Female, Ischemia pathology, Kidney pathology, Kidney surgery, Male, Rats, Rats, Wistar, Time Factors, Deferoxamine therapeutic use, Iron Chelating Agents therapeutic use, Ischemia prevention & control, Kidney blood supply
Abstract

Oxygen free-radical reperfusion products play a critical role in postischemic tissues injury. In this study we used deferoxamine, an iron ligand that seems to inhibit hydroxyl radicals production, in renal normothermic acute ischemia in the rat. Our results demonstrated a significant protective effect of deferoxamine on kidneys subjected to normothermic acute ischemia.

Published
1999

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