1. Synthesis and in silico studies of pyrrolidine sulfonamide based dipeptides as β-gluscosidase inhibitors
- Author
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G. Madhu, A. Raghavendra Guru Prasad, P. Raveendra Reddy, L.K. Ravindranath, and B. Santosh Kumar
- Subjects
Pharmacology ,Sulfonyl ,chemistry.chemical_classification ,Models, Molecular ,Sulfonamides ,Pyrrolidines ,Stereochemistry ,In silico ,beta-Glucosidase ,Pharmaceutical Science ,Hydrogen Bonding ,Dipeptides ,Fitness score ,Pyrrolidine ,chemistry.chemical_compound ,Structure-Activity Relationship ,chemistry ,Docking (molecular) ,Drug Design ,Imidazole ,Humans ,Computer Simulation ,Indicators and Reagents ,Enzyme Inhibitors - Abstract
A series of novel pyrrolidine sulfonamide derivatives were designed, synthesized and screened in silico for their β-gluscosidase inhibitory activity. The results showed that the pyrrolidine derivatives exhibited moderate inhibitory activity against human β-gluscosidases inhibitors. The structure-activity relationships were also briefly discussed. The studies indicated that compounds of Series B with imidazole sulfonyl group were the most potent inhibitors compared to the other compounds under investigation.
- Published
- 2014