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Your search keyword '"P Larmignat"' showing total 4 results
Start Over Author "P Larmignat" Journal annales de medecine interne
4 results on '"P Larmignat"'

1. [Immediate cardiac toxicity of rubidazone. A case reversible by isoproterenol]

Author

P, Larmignat, P, Casassus, J L, Pourriat, G, Leroux, F, Chaux, and M, Cupa

Subjects
Drug Hypersensitivity, Leukemia, Myeloid, Acute, Antibiotics, Antineoplastic, Daunorubicin, Hemodynamics, Isoproterenol, Shock, Cardiogenic, Humans, Female, Middle Aged
Abstract

It is reported the first observation of cardiogenic shock without delay, in a leukemic patient during a first injection of Rubidazone (22050 RP) which is recognized so far, as one of the least cardiotoxic anthracyclines. It has been concluded: --anthracyclines, beside the risk of a progressive cardiomyopathy which is related to the dose and very well known, can induce immediate cardiac injuries, which cannot be predicted yet; --the perfect myocardial protector is still to be discovered; --in this case, beta-adrenergic stimulators appeared to be able to control the cardiotoxic effect of Rubidazone; --the last fact could be considered in the decision to maintain the treatment when such an injury occurs during a chemotherapy or when it seems absolutely necessary to use such a drug.

Published
1983

2. [Primary hemostatic disorders caused by beta-lactams. Apropos of a postoperative hemorrhagic complication during treatment with cephalexin]

Author

A, Dupuy, G, Le Roux, P, Larmignat, O, Petitjean, A C, Masquelet, J Y, Nordin, P, Lortholary, and M, Cupa

Subjects
Cephalexin, Hematoma, Postoperative Complications, Platelet Aggregation, Humans, Female, Blood Coagulation Disorders, Aged, Anti-Bacterial Agents
Abstract

The authors report a case of haemorrhage due to cephalexin therapy. The bleeding started after an orthopedic operation in a patient without renal failure, receiving 3 g/day of cephalexin. Platelet function was very abnormal at the time of the haemorrhage with a bleeding time of over 20 minutes, which returned to normal when treatment was stopped. This case seems to be similar to other reports of haemorrhages during treatment with other beta-lactams.

Published
1985

3. [Immediate cardiac toxicity of rubidazone. A case reversible by isoproterenol].

Author

Larmignat P, Casassus P, Pourriat JL, Leroux G, Chaux F, and Cupa M

Subjects
Daunorubicin adverse effects, Daunorubicin analogs & derivatives, Female, Hemodynamics drug effects, Humans, Leukemia, Myeloid, Acute drug therapy, Middle Aged, Shock, Cardiogenic prevention & control, Antibiotics, Antineoplastic adverse effects, Drug Hypersensitivity etiology, Isoproterenol pharmacology, Shock, Cardiogenic chemically induced
Abstract

It is reported the first observation of cardiogenic shock without delay, in a leukemic patient during a first injection of Rubidazone (22050 RP) which is recognized so far, as one of the least cardiotoxic anthracyclines. It has been concluded: --anthracyclines, beside the risk of a progressive cardiomyopathy which is related to the dose and very well known, can induce immediate cardiac injuries, which cannot be predicted yet; --the perfect myocardial protector is still to be discovered; --in this case, beta-adrenergic stimulators appeared to be able to control the cardiotoxic effect of Rubidazone; --the last fact could be considered in the decision to maintain the treatment when such an injury occurs during a chemotherapy or when it seems absolutely necessary to use such a drug.

Published
1983

4. [Primary hemostatic disorders caused by beta-lactams. Apropos of a postoperative hemorrhagic complication during treatment with cephalexin].

Author

Dupuy A, Le Roux G, Larmignat P, Petitjean O, Masquelet AC, Nordin JY, Lortholary P, and Cupa M

Subjects
Aged, Anti-Bacterial Agents adverse effects, Female, Humans, Platelet Aggregation drug effects, Postoperative Complications, Blood Coagulation Disorders chemically induced, Cephalexin adverse effects, Hematoma chemically induced
Abstract

The authors report a case of haemorrhage due to cephalexin therapy. The bleeding started after an orthopedic operation in a patient without renal failure, receiving 3 g/day of cephalexin. Platelet function was very abnormal at the time of the haemorrhage with a bleeding time of over 20 minutes, which returned to normal when treatment was stopped. This case seems to be similar to other reports of haemorrhages during treatment with other beta-lactams.

Published
1985

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