1. Southeast asian ovalocytosis: the need for a carefull observation of red cell indices and blood smear
- Author
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Pierre-Antoine Moulin, Véronique Baccini, Denis Bernot, Vanessa Nivaggioni, Charlotte Grosdidier, Noémie Saut, CHU Marseille, Nutrition, obésité et risque thrombotique (NORT), and Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Adult ,Erythrocyte Indices ,Male ,Pathology ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Cytodiagnosis ,Population ,Usually asymptomatic ,Biology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Pregnancy ,parasitic diseases ,medicine ,Humans ,030212 general & internal medicine ,education ,Band 3 ,education.field_of_study ,Incidental Findings ,Blood Cells ,Hematologic Tests ,RED-CELL INDICES ,Pregnancy Complications, Hematologic ,Elliptocytosis, Hereditary ,General Medicine ,Middle Aged ,medicine.disease ,Southeast Asian ovalocytosis ,Blood smear ,Ovalocytosis ,biology.protein ,Female ,Hemoglobin - Abstract
Southeast asian ovalocytosis (SAO) is characterized by macro-ovalocytes and ovalo-stomatocytes on blood smear. SAO is common in Malaisia and Papua-New-Guinea where upwards to 40 per cent of the population is affected in some coastal region. Inherited in an autosomal dominant way, illness results from deletion of codons 400-408 in SLC4A1 gene which encodes for band 3 erythrocyte membrane protein. This deletion is responsible for an unusual erythrocyte stiffness and oval shape of the cells on blood smear. Heterozygous carriers are usually asymptomatic whereas homozygous are not viable without an intensive antenatal care. Here, we describe 4 patients diagnosed incidentally by cytogram appearance of the Advia® 2120i (Siemens) representing hemoglobin concentration according to red blood mean cellular volume (GR/VCH).
- Published
- 2017