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Aim The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients. Methods Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4). Results The average age was 59.58 ± 7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46 g/L ± 0.86 in G1; 3.73 g/L ± 1.11 in G2; 3.06 g/L ± 0.98 in G3 and 2.46 g/L ± 0.51 in G4; with a significant difference between the four groups ( P = 0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk ( P = 0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P = 0.005 and P = 0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia ( P = 0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 ( P = 0.035). Conclusion In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.