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Simple Summary: Canine aural hematoma management usually involves invasive surgery or prolonged pharmacologic treatments and is often linked to a high relapse rate. A correct diagnosis, associated with proper follow-up, is crucial for the success of the treatment. In this work, we report the treatment of 11 dogs (12 ears) affected by both acute and chronic aural hematoma with an innovative therapy based on Platelet- Rich Plasma (PRP). Ultrasound guidance was used to identify the presence of multiple and non-communicating chambers. Furthermore, in patients with pendulous ears, a bandage was applied to facilitate the post-treatment management. The results obtained in the study suggest that the PRP injection can be an effective alternative for the treatment of both chronic and acute aural hematoma without relapses in the long-term follow-up. Aural hematoma is a common pathological condition in veterinary practice with a high incidence rate in dogs. Drainage, corticosteroid injections, and surgical approaches represent the common treatments in these clinical cases. However, surgery leaves visible signs and is usually correlated with recurrence, scars, and deformation of the treated pinna. For this reason, more effective and less invasive methods have been proposed over the years. Platelet-Rich Plasma (PRP) is one of the most promising options due to its pro-regenerative properties and capability to modulate the inflammatory state. The present work reports 12 cases of canine aural hematoma treated with PRP. The PRP treatment was combined with an ultrasound evaluation of the pinna to detect and treat all involved septa. The results show that relatively large volumes (2 mL) of PRP associated with an ultrasound guide are safe and efficacious in the treatment of canine aural hematoma requiring a maximum of two infiltrations, both in acute and chronic conditions. All the patients recovered their normal ear thickness (compared with the controlateral one) without relapses, averaging 38.5 days from their first treatment (10–90 days; SD: 24.7). The key role of PRP combined with a tailored diagnosis process carried out by the veterinarian, which included using an ultrasound system and the proper bandage, suggests that this approach may represent a valid alternative to surgery and corticosteroids. [ABSTRACT FROM AUTHOR]

Simple Summary: Triclosan is widely used in cosmetics and hygiene products, including anti-bacterial hand sanitizers and disinfectants whose utilization has been greatly increased during the COVID-19 pandemic. Since critical health effects have been demonstrated for this substance we tested its potential harmful action on ovarian cells collected from pigs, a valuable animal model. We demonstrated that Triclosan impairs cell function, thus suggesting an impairment of reproductive function. Triclosan is a chlorinated biphenolic with a broad spectrum of antiseptic activities used in cosmetics and hygiene products. Continuous exposure can lead to absorption and bioaccumulation of this substance with harmful health effects. In fact, previous studies have shown that Triclosan acts as an endocrine-disrupting chemical on reproductive organs, with consequent negative effects on reproductive physiology. Therefore, to assess potential adverse impacts on fertility, we tested Triclosan on swine granulosa cells, a model of endocrine reproductive cells. We examined its effects on the main features of granulosa cell functions such as cell growth (BrdU incorporation and ATP production) and steroidogenesis (17-β estradiol and progesterone secretion). Moreover, since oxidant–antioxidant balance plays a pivotal role in follicular function, redox status markers (superoxide, hydrogen peroxide and nitric oxide production, enzymatic and non-enzymatic scavenging activity) were studied. Our results show that Triclosan significantly inhibits cell growth (p < 0.001), steroidogenesis (p < 0.001), superoxide and nitric oxide production (p < 0.001), while it increases (p < 0.05) enzymatic defense systems. Collectively, these data suggest a disruption of the main granulosa cell functions, i.e., proliferation and hormone production, as well as an imbalance in redox status. On these bases, we can speculate that Triclosan would impair granulosa cell functions, thus exerting negative effects on reproductive function. Further studies are needed to explore lower Triclosan concentrations and to unravel its mechanisms of action at gene level. [ABSTRACT FROM AUTHOR]