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Start Over Author "Varona, A." Journal animal genetics
21 results on '"Varona, A."'

13. Joint analysis of additive, dominant and first-order epistatic effects of four genes (IGF2,MC4R,PRKAG3andLEPR) with known effects on fat content and fat distribution in pigs

Author

A. Galve, Pascual López-Buesa, Luis Varona, and Carmen Burgos

Subjects
Meat, Swine, Fat content, Adipose tissue, AMP-Activated Protein Kinases, Biology, Quantitative Trait, Heritable, Insulin-Like Growth Factor II, Genetics, Animals, Body Fat Distribution, Gene, chemistry.chemical_classification, Fatty acid, Bayes Theorem, Epistasis, Genetic, General Medicine, Adipose Tissue, chemistry, Saturated fatty acid, Receptor, Melanocortin, Type 4, Receptors, Leptin, Epistasis, Animal Science and Zoology, Composition (visual arts), Intramuscular fat
Abstract

LEPR, MC4R, IGF2 and PRKAG3 are genes with known effects on fat content and distribution in pig carcass and pork. In a study performed with Duroc × Landrace/Large White pigs, we have found that IGF2 has strong additive effects on several carcass conformational traits and on fatty acid composition in several anatomical locations. MC4R shows additive effects on saturated fatty acid content in several muscles. On the other side, almost no additive effect has been found for PRKAG3 and very few for LEPR. In this work, no dominant effect has been found for any of the four genes. Using a Bayesian Lasso approach, we have been able now to find first-order epistatic (mainly dominant-additive) effects between LEPR and PRKAG3 for intramuscular fat content and for saturated fatty acid content in L. dorsii, B. femoralis, Ps. major and whole ham. The presence of interactions between genes in the shaping of traits of such importance as intramuscular fat content and composition highlights the complexity of heritable traits and the difficulty of gene-assisted selection for such traits.

Published
2013
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14. Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs

Author

Armand Sánchez, Oriol Vidal, Marcel Amills, Luis Varona, J. L. Noguera, and Maria Angels Oliver

Subjects
Genetics, education.field_of_study, Meat, Genotype, Sus scrofa, Haplotype, Population, Malic enzyme, Locus (genetics), Single-nucleotide polymorphism, General Medicine, Biology, Quantitative trait locus, Polymorphism, Single Nucleotide, Tricarboxylate, Malate Dehydrogenase, Body Composition, Animals, Animal Science and Zoology, education, DNA Primers
Abstract

Malic enzyme 1 (ME1) is a part of the tricarboxylate shuttle that provides NADPH and acetyl-CoA required in fatty acid biosynthesis. The pig ME1 locus maps on the proximal end of chromosome 1, where a quantitative trait loci (QTL) affecting fat deposition has been previously described. We amplified fragments of 1457 and 1459 bp that corresponded to the complete coding region and the 3'-untranslated region (UTR), respectively, of the pig ME1 gene. The sequences of these two fragments in pigs from three breeds (Landrace, Large White and Piétrain) contained five single nucleotide polymorphisms (SNP) in the 3'-UTR: C1706T, G1762T, A1807C, C1857A and T1880A. Three haplotypes were found in two generations of a selected Landrace population: H1 (C1706 G1762 A1807 C1857 A1880), H2 (C1706 G1762 A1807 C1857 T1880) and H3 (T1706 T1762 C1807 A1857 T1880). Using Bayesian association analyses, significant associations (highest posterior density at 95%) between ME1 genotype and backfat (BF) thickness at 171 days and muscular pH were found in a Landrace population.

Published
2006
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16. Assignment of the 2,4-dienoyl-CoA reductase (DECR) gene to porcine chromosome 4

Author

A, Clop, A, Cercós, A, Tomàs, M, Pérez-Enciso, L, Varona, J L, Noguera, A, Sànchez, and M, Amills

Subjects
Fatty Acid Desaturases, Oxidoreductases Acting on CH-CH Group Donors, Radiation Hybrid Mapping, Polymorphism, Genetic, Swine, Molecular Sequence Data, Animals, Chromosome Mapping
Published
2002

21. QTL mapping for teat number in an Iberian-by-Meishan pig intercross.

Author

Rodr&00#xED;guez, C., Tomás, A., Alves, E., Ramirez, O., Arqué, M., Muñoz, G., Barragán, C., Varona, L., Silió, L., Amills, M., and Noguera, J. L.

Subjects
CHROMOSOMES, KARYOKINESIS, GENETICS, CELL nuclei, ORGANELLES, GENE mapping, GENOMICS, CELL division
Abstract

The aim of this study was to investigate chromosomal regions affecting the number of teats in pigs and possible epistatic interactions between the identified quantitative trait loci (QTL). An experimental F2 cross between Iberian and Chinese Meishan lines was used for this purpose. A genomic scan was conducted with 117 markers covering the 18 porcine autosomes. Linkage analyses were performed by interval mapping using an animal model to estimate QTL and additive polygenic effects. Complementary analyses with models fitting two QTL were also carried out. The results showed three genomewide significant QTL mapping on chromosomes 5, 10 and 12, whose joint action control up to 30% of the phenotypic variance of the trait. Meishan alleles had a positive additive effect on teat number, and a positive-additive × additive-epistatic interaction was detected between QTL on chromosomes 10 and 12. [ABSTRACT FROM AUTHOR]

Published
2005
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