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3 results on '"R. Snell"'

1. Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus

Author

M, Littlejohn, T, Grala, K, Sanders, C, Walker, G, Waghorn, K, Macdonald, W, Coppieters, M, Georges, R, Spelman, E, Hillerton, S, Davis, and R, Snell

Subjects
DNA-Binding Proteins, Dairying, Polymorphism, Genetic, Genotype, Body Weight, Animals, Cattle, Female, Feeding Behavior, Weight Gain, Chromosomes, Mammalian, Polymorphism, Single Nucleotide
Abstract

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements.

Published
2012

2. Non-replication of genome-wide-based associations of efficient food conversion in dairy cows.

Author

Littlejohn M, Grala T, Sanders K, Walker C, Waghorn G, Macdonald K, Spelman R, Davis S, and Snell R

Subjects
Animals, Dairying, Diet veterinary, Food, Genetic Markers, Polymorphism, Single Nucleotide, Cattle genetics, Cattle metabolism, Genome-Wide Association Study veterinary, Milk metabolism
Abstract

Animal growth relative to food energy input is of key importance to agricultural production. Several recent studies highlighted genetic markers associated with food conversion efficiency in beef cattle, and there is now a requirement to validate these associations in additional populations and to assess their potential utility for selecting animals with enhanced food-use efficiency. The current analysis tested a population of dairy cattle using 138 DNA markers previously associated with food intake and growth in a whole-genome association analysis of beef animals. Although seven markers showed point-wise significance at P < 0.05, none of the single-nucleotide polymorphisms tested were significantly associated with food conversion efficiency after correction for multiple testing. These data do not support the involvement of this subset of previously implicated markers in the food conversion efficiency of the physiologically distinct New Zealand Holstein-Friesian dairy breed., (© 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.)

Published
2012
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3. Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.

Author

Littlejohn M, Grala T, Sanders K, Walker C, Waghorn G, Macdonald K, Coppieters W, Georges M, Spelman R, Hillerton E, Davis S, and Snell R

Subjects
Animals, Body Weight, Cattle metabolism, Chromosomes, Mammalian genetics, Dairying, Feeding Behavior, Female, Genotype, Polymorphism, Single Nucleotide, Weight Gain, Cattle genetics, Cattle growth & development, DNA-Binding Proteins genetics, Polymorphism, Genetic
Abstract

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements., (© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.)

Published
2012
Full Text
View/download PDF

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